Position: Associate Professor
School/Academic Group: School of Pharmaceutical Sciences
Email： xiangjin@whu.edu.cn
Education:
2001 - 2006 Wuhan University，Ph.D.
Working Experience:
2006-2016 Wuhan University, Lecturer
2016-now Wuhan University, Associate Professor
Current Teaching Interests/Responsibilities:
Biopharmaceutics and Pharmacokinetics
Research Interests:
The regulatory mechanism of estrogen on cellular autophagy.
The discovery of new anti-cancer drugs based on structural basis and related molecular pharmacology research.
The establishment of a personalized cancer medication database.
Publications:
1. Zhao Y, Wang X, Liu Y, Wang HY, Xiang J#. The effects of estrogen on targeted cancer therapy drugs. Pharmacol Res. 2022 Mar;177:106131.
2. Qi M, Liu X, Zhou Y, Wang H, Zhao Y, Ren J, Xiang J#. Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1. Int J Mol Sci. 2021 Oct 24;22(21):11466.
3. Luo M, Xu H, Dong Y, Shen K, Lu J, Yin Z, Qi M, Sun G, Tang L, Xiang J, Deng Z, Dickschat JS, Sun Y. The Mechanism of Dehydrating Bimodules in trans-Acyltransferase Polyketide Biosynthesis: A Showcase Study on Hepatoprotective Hangtaimycin. Angew Chem Int Ed Engl. 2021 Aug 23;60(35):19139-19143.
4. Zhao Y, Zhao C, Lu J, Wu J, Li C, Hu Z, Tian W, Yang L, Xiang J, Zhou H, Deng Z, Huang J, Hong K. Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader. Pharmacol Res. 2019 Aug;146:104294.
5. Xiang J#, Liu X, Ren J, Chen K, Wang HL, Miao YY, Qi MM. How does estrogen work on autophagy? Autophagy. 2019 Feb;15(2):197-211.
6. Xiang J, Chun E, Liu C, Jing L, Al-Sahouri Z, Zhu L, Liu W. Successful Strategies to Determine High-Resolution Structures of GPCRs. Trends Pharmacol Sci. 2016 Dec;37(12):1055-1069.
7. Xiang J, Wang Y, Su K, Liu M, Hu PC, Ma T, Li JX, Wei L, Zheng Z, Yang F. Ritonavir binds to and downregulates estrogen receptors: molecular mechanism of promoting early atherosclerosis. Exp Cell Res. 2014 Oct 1;327(2):318-30.
8. Zhang JW, Su K, Shi WT, Wang Y, Hu PC, Wang Y, Wei L, Xiang J#, Yang F. Matrine inhibits the adhesion and migration of BCG823 gastric cancer cells by affecting the structure and function of the vasodilator-stimulated phosphoprotein (VASP). Acta Pharmacol Sin. 2013 Aug;34(8):1084-92.
9. Jia T, Xiang J, Wang J, Guo P, Yu J. Interactions of newly designed dicationic carbazole derivatives with double-stranded DNA: syntheses, binding studies and AFM imaging. Org Biomol Chem. 2013 Sep 7;11(33):5512-20.
10. Huang T, Xu J, Xiang J, Lu Y, Chen R, Huang L, Xiao G, Sun G. PrPC interacts with potassium channel tetramerization domain containing 1 (KCTD1) protein through the PrP(51-136) region containing octapeptide repeats. Biochem Biophys Res Commun. 2012 Jan 6;417(1):182-6.
11. Xiang J, Sun G, Mu Y, Liu H, Liu Y, Yang F, Xu J, Ding H. Ritonavir stimulates foam cell formation by activating PKC. Chem Biol Interact. 2011 Nov 15;194(2-3):127-33.
12. Liu Y, Xiang J, Liu M, Wang S, Lee RJ, Ding H. Protective effects of glycyrrhizic acid by rectal treatment on a TNBS-induced rat colitis model. J Pharm Pharmacol. 2011 Mar;63(3):439-46.
13. Liu M, Xiang J, Zhou J, and Ding H, A disposable amperometric sensor for rapid detection of serotonin in the blood and brain of the depressed mice based on Nafion membrane-coated colloidal gold screen-printed electrode. Electroanal Chem. 2010, 640, 1-7.
14. Xiang J, Yu C, Yang F, Yang L, Ding H, Conformation-activity studies on the interaction of berberine with acetylcholinesterase: Physical chemistry approach. Prog Nat Sci. 2009, 19: 1721-1725.
15. Xiang J, Fan J-B, Chen N, Chen J, and Liang Y, Interaction of cellulase with sodium dodecyl sulfate at critical micelle concentration level. Colloids Surface B. 2006, 49, 175-180.
