Position: Associate Professor
School/Academic Group: School of Pharmaceutical Sciences
Email：waw6@whu.edu.cn
Education:
2000 Wuhan University, Bachelor
2005 Wuhan University, Ph.D.
Working Experience:
2011 - present, Wuhan University, Associate Professor
2008 - 2011, University of Pittsburgh, USA, Postdoc
2006 - 2008, Southern Illinois University Carbondale, USA, Postdoc
2005-2006, Shanghai Wuxi WuXi AppTec New Drug Development Co., Ltd.Senior Researcher
Current Teaching Interests/Responsibilities:
Computer-aided Medicine Design
Research Interests:
Integrate synthetic chemistry and computer-aided drug design technology to carry out drug design and discovery for the interaction targets of anti-virus drugs and tumor proteins, carry out "translation" research from functional protein domains to active small molecules, and mainly carry out drug design and synthesis of corresponding functional small molecules for protein-protein interaction.
Publications:
1.Feature-derived graph regularized matrix factorization for predicting drug side effects, Neurocomputing, Wen Zhang, Qianlong Qu, Yunqiu Zhang, Wei Wang, 2018, 287, 154-162
2.The linear neighborhood propagation method for predicting long non-coding RNA –protein interactions, Neurocomputing, Wen Zhang, Qianlong Qu, Yunqiu Zhang, Wei Wang, 2018, 273, 526-534
3.Recent Advances in Gossypol Derivatives and Analogues: A Chemistry and Biology View. Lu Y., Li J., Dong C., Huang J., Zhou H.-B.,* Wang W.* Future Med. Chem. 2017, V9, No11.1243-1275
4.Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins, Yuzhi Lu, Shuangchan Wu, Yuan Yue, Si He, Jun Li, Jun Tang, Wei Wang*, and Hai-Bing Zhou*,ACS Med. Chem. Lett., 2016, 7 (12), pp 1185–1190,
5.Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors, Yu Li, Guiquan Xia, Qi Guo, Li Wu, Shizhen Chen, Zhigang Yang, Wei Wang, Zhong-Yin Zhang, Xin Zhouc, Zhong-Xing Jiang*, Med. Chem. Commun., 2016,7, 1672-1680,
6.Isocyanides as Influenza A Virus Subtype H5N1 Wild-Type M2 Channel Inhibitors, Shuwen Wu, Jing Huang, Sabrina Gazzarrini, Si He, Lihua Chen, Dr. Jun Li, Li Xing, Chufang Li, Ling Chen, Constantinos G. Neochoritis, George P. Liao, Haibing Zhou, Alexander Dömling, Anna Moroni, Wei Wang*,CHEMMEDCHEM, 2015, 10(11), 1837-1845,
7.HIV衣壳蛋白结构及其药物小分子进展, 李俊，王巍*，药学学报，2015, 50(9),1088-1095
Progress in the study of HIV capsid structure and drug discovery, Jun Li, Wei Wang, yao xue xue bao, 2015, 50(9), 1088-1095
8.Recyclable BINOL–quinine–squaramide as a highly efficient organocatalyst for α-amination of 1,3-dicarbonyl compounds and α-cyanoacetates, Yongzhi Gao, Bin Liu, Hai-Bing Zhou, Wei Wang, Chune Dong*, RSC Advances, 2015, 31(5), 24392-24398,
9.Synthesis and SARs of indole-based α-amino acids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors, Xin Han, Haoming Wu, Wei Wang, Chune Dong, Po Tien, Shuwen Wu*, Hai-Bing Zhou*, Organic Biomolecular Chemistry, 2014, 41(12), 8308-8317,
10.(3+2) Annulation of Amidinothioureas with Binucleophile: Synthesis and Antimicrobial Activity of 3-Phenylamino-5-aryl/alkyl-1,2,4-oxadiazole Derivatives, Swapnil G. Yerande, Amruta B. Ghaisas, Kiran M. Newase, Wei Wang, Kan Wang, Alexander Dömling, Journal of Heterocyclic Chemistry, 2014, 51(6), 1752-1756
11.Mercury(II) Chloride-Mediated Desulphurization of Amidinothioureas: Synthesis andAntimicrobial Activity of 3-Amino-1,2,4-triazole Derivatives, Swapnil G. Yerande, Chetna D. Baviskar, Kiran M. Newase, Wei Wang, Kan Wang, Alexander Dömling, Journal of Heterocyclic Chemistry, 2014, 51(6), 1883-1887
12.Enantioselective inhibition of reverse transcriptase (RT) of HIV-1 by non racemic indole-based trifluoropropanoates developed by asymmetric catalysis using recyclable organocatalysts, Xin Han, Wenjie Ouyang, Bin Liu, Wei Wang*, Bo Tian , Shuwen Wu *, Hai-Bing Zhou*, Organic Biomolecular Chemistry, 2013, , 2013, 11, 8463-8475
13.N-Butyl-2,4-dinitro-anilinium p-toluenesulfonate as a highly active and selective esterification catalyst, Narsimha Sattenapallya, Wei Wang, Huimin Liu, and Yong Gao*, Tetrahedron Letters, 2013, 54(48), 6665-6668
14.Esterification Catalysis by Pyridinium p-Toluenesulfonate Revisited Modification with a Lipid Chain for Improved Activities and Selectivities, Wei Wang, Huimin Liu, Shaoyi Xu, and Yong Gao, Synthetic Communications, 2013, 43(21), 2906-2912
15.P53-Mdm2 Active Benzimidazol-2-ones, Wei Wang, Haiping Cao, Siglinde Wolf, Miguel S. Camacho-Horvitz, Tad Holak, and Alexander Dömling, Bioorganic & Medicinal Chemistry, 2013, 21, 14, 3982-3995
16.Chemisty & Biology of Multicomponent Reactions, Alexander Dömling, Wei Wang#, Kan Wang# , (equally contribution) Chemical Reviews, 2012, 112 (6), pp 3083–3135
17.Enabling Large-Scale Design, Synthesis and Validation of Small Molecule Protein-Protein Antagonists, D. Koes, K. Khoury, Y. Huang, Wei Wang, M. Bista, G. M. Popowicz, S. Wolf , T. A. Holak, A. Dömling, C.J. Camacho, Plos One, 2012 , 7(3), e32839
18.Polycyclic Compounds by Ugi−Pictet−Spengler Sequence, Wei Wang, Sarah Ollio, Alexander Dömling, The Journal of Organic Chemistry, 2011, 76 (2), 637–644, (Selected by Synfact, 2011, 4, 376)
19.Two Strategies for the Development of Mitochondrial-Targeted Small Molecule Radiation Damage Mitigators, Jean-Claude M. Rwigema, Barbara Beck, Wei Wang, Alexandaer Doemling, Michael W. Epperly, Donna Shields, Darcy Franicola, Tracy Dixon, Marie-Celine Céline Frantz, Peter Wipf, Yulia Tyurina, Valerian Kagan, Hong Wang, and Joel S. Greenberger, International Journal of Radiation Oncology*Biology*Physics, 2011, 80(3), 860-868
20.Structures of Low Molecular Weight Inhibitors Bound to MDMX and MDM2 Reveal New Approaches for p53-MDMX/MDM2 Antagonist Drug Discovery, G. M. Popowicz, A. Czarna, S. Wolf, K. Wang, Wei Wang, A. Dömling, T. A. Holak, Cell Cycle, 2010, 9(6), 1104 – 1111.
21.Polycyclic indole alkaloid-type compounds by MCR, Wei Wang, Eberhardt Herdtweck , Alexander Dömling, Chemical Communications, 2010, 46, 770-772.
22.Bacillamide C and Derivatives: The Convergent Approach, Wei Wang, Shannon Joyner, Kareem Andrew Sameer Khoury, Alexander Dömling, Organic Biomolecular Chemistry, 2010, 8, 529-532.
23.Rapid and efficient hydrophilicity tuning of p53/MDM2 antagonists, Stuti Srivastava, Barbara Beck, Wei Wang, Ania Czarna, Tad Holak, Alexander Dömling, Journal of Combinatorial Chemistry, 2009, 11 (4), pp 631–639
24.Efficient Synthesis Of Arrays Of Amino Acid Derived Ugi Products With Subsequent Amidation, Wei Wang, Alexander Dömling, Journal of Combinatorial Chemistry, 2009, 11 (3), p 403-409
25.A Fast and Efficient Approach to Small Molecular Weight Protein-Protein Interaction Antagonists Using MCR Chemistry. Barbara Beck, Stuti Srivastava, Wei Wang, Kan Wang, Anna Czarna, Tad A. Holak, Lidio Meireles, Carlos Camacho, Balu Raghavan, Billy W. Day and Alexander Dömling, In MCR 2009; Mironov, M. A., Ed.; Advances in Experimental Medicine and Biology, 2011, Volume 699, 82.
26.Progress in biscalixarene research, Zheng, Qin; Gong, Shuling.; Zhang, Chunlei; Wang, Wei; Chen, Yuanyin, Progress in Chemistry (In Chinese) 2007, 19, (5), 722-734,.
27.The Effect of Hydrogen bonds in the Reaction of Phenols with Epoxy in the Presence of Nano CaCO3,Wei Wang, Shuling Gong*, Yuanyin Chen, Supramolecular Chemistry，2006, 18(4)311-315.
28.Fibriform One-dimentional Hydrogen-bonded Network Composed of 1,2-alt Calix[4]arene Tetra Acetic Acid, Wei Wang, Shuling Gong*, Yuanyin Chen, Jianpin Ma, New Journal of Chemistry, 2005, 29:1390-1392.
29.Preparation and Characterization of Biscalix[4]arene with Alkyne-containing Spacer, Wang Wei, Gong Shuling, Meng Lingzhi, Chen Yuanyin*, Chemical Journal of Chinese Universities, 2005, 26(8): 1467-1470. (In Chinese)
30.Solid-Phase Microextraction of Aromatic Amines with Amide Bridged Calix[4]arenes Coated Fiber, Wei Wang, Shuling Gong*, Qihua Cao, Yuanyin Chen, Xiujuan Li, and Zhaorui Zeng, Chromatography, 61(1-2):85-80 2005.
31.Diamide bridged calix[8]arenes, Li Jun, Wang Wei, Gong Shuling, Chen Yuanyin*, Wu Xiaojun, Synlett, 2004, (2): 332-334.
32.Characteristics and Applications of Amide Bridged Calix[4]arene Solid-Phase Microextration Fiber, Xiujuan Li, Shuling Gong, Wei Wang, Zhaorui Zeng*, Chinese Journal of Chromatography, (In Chinese), 2004, 22(5) 472-475
33.Nano CaCO3: An unique condensation agent for the preparation of monosubstituted calix[4]arene by ring-opening reaction, Gong SL*, Wang Wei, Fang Pengfei, Chen Yuanyin, Chinese Chemical Letters, 2003, 14 (1): 20-21 JAN.
34. Nano CaCO3: playing a special role in the monofunctionalization of calixarenes by epoxides, Gong SL*, Wang Wei, Chen Yuanyin, Meng Lingzhi, Wan Tao, New Journal of Chemistry, 2002, 26 (12): 1827-1830.
35.Novel fiber coated with amide bridged-calix[4]arene used for solid-phase microextraction of aliphatic amines, Xiujuan Li, Zhaorui Zeng*, Jingjing Zhou, Shuling Gong, Wei Wang, Yuanyin Chen, Journal of Chromatography A, 2004, 1041(1-2): 1-9.
