Position: Professor
School/Academic Group: School of Pharmaceutical Sciences
Email: benhongzh@whu.edu.cn
Education：
1984.09 - 1988.06 Hubei University of Chinese Medicine, Bachelor
1997.09 - 1999.12 Wuhan University School of Medicine, Master
2002.09 - 2007.12 Wuhan University, Ph.D.
Professional Memberships and/or Notable Appointments:
Ministry of Education, Subcommittee on Clinical Pharmacy, Teaching Steering Committee for Pharmacy Programs, Member
Hubei Pharmaceutical Association, Committee on Traditional Chinese Medicine and Natural Medicines, Chairman
Hubei Pharmaceutical Association, Deputy Secretary-General
Wuhan Pharmaceutical Association, Vice President
Chinese Hospital Association, Committee on Pharmaceutical Affairs, Member
Chinese Pharmaceutical Association, Committee on Pharmacoepidemiology, Member
China Association of Chinese Medicine, Committee on Clinical Pharmacology of Traditional Chinese Medicine, Member
Hubei Pharmacological Society, Subcommittee on Therapeutic Drug Monitoring Research, Vice Chairman
Hubei Association of Traditional Chinese Medicine, Committee on Traditional Chinese Medicine, Vice Chairman
Hubei Science Writers Association, Subcommittee on Medical Science Popularization, Vice Chairman
Journal of Chinese Medicinal Materials; Herald of Medicine; China Pharmacy, Editorial Board Member
Working Experience：
1988.06 - 1994.11 Renmin Hospital of Wuhan University, Pharmacist
1994.11 - 1999.11 Renmin Hospital of Wuhan University, Chief Pharmacist
1999.12 - 2001.03 Renmin Hospital of Wuhan University, Department of Pharmacy, Associate Chief Pharmacist and Associate Professor
2001.03 - 2015.04 Renmin Hospital of Wuhan University, Deputy Director, Clinical Pharmacy Research Division
2015.04 - 2020.12 Renmin Hospital of Wuhan University, Deputy Director of Pharmacy Department & Clinical Pharmacy Research Division
2021.01 - Present Wuhan University, School of Pharmaceutical Sciences, Department of Clinical Pharmacy, Director; Renmin Hospital of Wuhan University, Director of Pharmacy Department, Director of Dispensing Division, Director of Shouyi Campus Dispensing Division, Deputy Director of Clinical Pharmacy Research Division
Current Teaching Interests/Responsibilities:
Undergraduate Courses: Drug Control Studies
Graduate Courses: Modern Technologies in Traditional Chinese Medicine
Research Interests:
Active Components of Traditional Chinese Medicine and Natural Products; Clinical Pharmacy and Drug Metabolism
Publications：
1. Zhang B, Liu M, Liu G, Li D, Zhou B*. Oral absorption mechanism of the polysaccharides from Gastrodia elata Blume base on fluorescence labeling. Food Res Int. 2021 Jun;144:110342. （IF: 4.972，2区）
2. Zeng, M.L , Su, Y. , Li, K.Y , Jin, D. , Zhou B.H*. Gallic acid inhibits bladder cancer T24 cell progression through mitochondrial dysfunction and pi3k/akt/nf-κb signaling suppression. Frontiers in Pharmacology, 2020,11, 1222. （IF: 4.223，2区）
3. Wu Y , Tian S , Rong PP , Zhang F, Chen Y, Guo XX, Zhou BH*. Sacubitril-Valsartan Compared With Enalapril for the Treatment of Heart Failure: A Decision-Analytic Markov Model Simulation in China[J]. Frontiers in Pharmacology, 2020, 11,1101. （IF: 4.223，2区）
4. Zhou B.H*, Li Q.L, Wang J, Chen P, Jiang S. Ellagic acid attenuates streptozocin induced diabetic nephropathy via the regulation of oxidative stress and inflammatory signaling. Food and Chemical Toxicology, 2019, 123:16-27. （IF: 4.679，top2区）
5. Peng Chen, Fuchao Chen, Ben-Hong Zhou*.Leonurine ameliorates D-galactose-induced aging in mice through activation of the Nrf2 signalling pathway. Aging us, 2019,11(18),7339-7356-11.（IF: 4.831,2区）
6. Li Qiaoling, Li Kuangyu, Cheng Zhenzhen, Zhou Benhong*. Anti-renal fibrosis and anti-inflammation effect of urolithin B, ellagitannin-gut microbial-derived metabolites in unilateral ureteral obstruction rats. Journal of functional foods. 2020,65: 103748.( IF: 3.701,2区top)
7. Chen, Peng., Chen, Fuchao., Lei, Jiexin., Li, Qiaoling., Zhou, Benhong*. Activation of the miR-34a-mediated SIRT1/mTOR signaling pathway by urolithin A attenuates D-galactose-induced brain aging in mice. Neurotherapeutics, 2019.
8. Chen,Peng., Lei, Jiexin., Zhou, Benhong*. Letter: decreased neonatal hepatitis B virus (HBV) viremia by maternal tenofovir treatment predicts reduced chronic HBV infection in children born to highly viremic mothers. Alimentary Pharmacology & Therapeutics, 2019,50(8):973-974.（7.515, IF: 1区top）
9. Chen P , Lei JX , Chen FC , Zhou BH*. Ameliorative effect of urolithin A on D-gal-induced liver and kidney damage in aging mice via its antioxidative, anti-inflammatory and antiapoptotic properties[J]. RSC Advances, 2020, 10(14):8027-8038. （IF: 3.119，3区）
10. Chen,Peng., Lei, Jiexin., Wu, Yue., Zhou, Benhong*. Pegylated G-CSF Combined with mFOLFIRINOX for Advanced Pancreatic Cancer Patients. INTERNAL MEDICINE.2020,59(6):877-877.( IF: 1.005,4区)
11. Li Qiaoling, Tu Jie, Zhou Benhong*. The tannins from Punica granatum L, natural regulator of TGF-β1/Smad signaling activity improves nephrectomy and adriamycin induced focal segmental glomerulosclerosis in vivo. Journal of functional foods, 2019. 57:361-372. (IF: 3.701,2区top)
12. Chen,Peng ; Chen,Fuchao; Zhou,Benhong*.Systematic review and meta-analysis of prevalence of dermatological toxicities associated withvemurafenib treatment in patients with melanoma. Clinical and experimental dermatology, 2019, 44(3):243-251. （IF: 1.977,4区）
13. Chen, Peng, Chen, Fuchao, Lei, Jiexin, Zhou, Benhong*. Efficacy and safety of dexmedetomidine combined with tramadol for patient-controlled intravenous analgesia in Chinese surgical patients A systematic review and meta-analysis. Medicine. 2020. 99（3）（1.552.，4区）
14. Li, Kuangyu., Zeng, Maolin., Li, Qiaoling., Zhou, Benhong*. Identification of polyphenolic composition in the fruits of Rubus chingii Hu and its antioxidant and antiproliferative activity on human bladder cancer T24 cells. Journal of Food Measurement and Characterization.2019, 13(1):51-60. （IF: 4区，1.648）
15. Chen Peng, Chen, Fuchao, Zhou, Benhong*. Compatibility and stability of dezo- cine and tropisetron in 0.9% sodium chloride injection for patient-controlled analgesia administration. Medicine, 2018, 97(50). （1.552.，4区）
16. Chen,Peng., Lei, Jiexin., Wu, Yue., Zhou, Benhong*. Pegylated G-CSF Combined with mFOLFIRINOX for Advanced Pancreatic Cancer Patients. Internal medicine . doi: 10.2169/internalmedicine.3790-19. 2019.（IF: 1.005,4区）
17. Chen, Peng; Chen, Fucaho; Zhou, Benhong*. The risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients: a systematic review and meta-analysis. Cutaneous and ocular toxicology, 2019, 38(2):105-111.（1.385,4区）
18. Chen, Peng., Chen, Fuchao., Zhou, Benhong*. Antioxidative, anti-inflammatory and anti-apoptotic effects of ellagic acid in liver and brain of rats treated by D-galactose. Scientific Reports.2018, 8:1465. （IF: 3.998,3区）
19. Zhou, Benhong*., Tan, Jun., Zhang, Chan., Wu, Yue. Neuroprotective effect of polysaccharides from Gastrodia elata Blume against corticosterone-induced apoptosis in PC12 cells via inhibition of the endoplasmic reticulum stress-mediated pathway. Molecular Medicine Reports, 2018，17:1182-1190.（IF: 2.1,4区）
20. Peng, Chen., Fuchao, Chen., Benhong Zhou*. Comparisons of therapeutic efficacy and safety of ipilimumab plus GM-CSF versus ipilimumab alone in patients with cancer: a meta-analysis of outcomes. Drug Design, Development and Therapy, 2018, 12:2025-2038. （IF: 3.216,3区）
21. Peng, chen., Fuchao, chen., Jiexin, lei., Benhong, Zhou*. Curative effectiveness and safety of osimertinib in the treatment for non-small-cell lung cancer: a meta-analysis of the experimental evidence. OncoTargets and Therapy，2018,11:9033-9047. （IF: 3.337,3区）
22. Chen, Peng., Chen, Fuchao., Zhou, Benghong*., Therapeutic efficacy and safety of combined BRAF and MEK inhibition in patients with malignant melanoma: a meta-analysis. OncoTargets and Therapy, 2017,10:5391-5403. （IF: 3.337,3区）
23. Zhou, Benhong*., Wang, Jing., Zheng, Guohu., Qiu, Zhenpeng. Methylated urolithin A, the modified ellagitannin-derived metabolite, suppresses cell viability of DU145 human prostate cancer cells via targeting miR-21. Food and Chemical Toxicology, 2016, 97:375-384. （IF: 4.679,2区top）
24. Chen, Peng., Chen,Fuchao., Zhou, Benhong*. Risk of gastrointestinal events during neratinib therapy in patients with cancer: a systematic review and meta-analysis of clinical trials. International journal of clinical and experimental medicine, 2019, 41(4):3546-3557.（IF: 0.116,4区）
25. Zhou, Benhong*., Yi, Huilan., Tan, Jun., Wu, Yue., Liu, Gang., Qiu, Zhenpeng., Anti-Proliferative Effects of Polyphenols from Pomegranate Rind (Punica granatum L.) on EJ Bladder Cancer Cells Via Regulation of p53/miR-34a Axis. Phytotherapy Research, 2015, 29(3):415-422.（IF: 4.087,3区）
26. Chen,Peng ; Chen,Fuchao; Zhou,Benhong*.Systematic review and meta-analysis of prevalence of dermatological toxicities associated withvemurafenib treatment in patients with melanoma. Clinical and experimental dermatology .2019, 44(3):243-251.（1.977,4区）
27. Fuchao Chen., Hui Xiong., Jinguo Yang., Baoxia Fang., Jun Zhu., Benhong Zhou*. Butorphanol and Ketamine Combined in Infusion Solutions for Patient-Controlled Analgesia Administration: A Long-Term Stability Study. Medical Science Monitor, 2015, 21:1138-1145. （IF: 1.918,4区）
28. Fuchao Chen., Baoxia Fang., Peng Li., Jinguo Yang., Benhong Zhou*. Compatibility of butorphanol and droperidol in 0.9% sodium chloride injection. American Journal of Health-System Pharmacy, 2015, 70(6):515-519. （IF: 2.314,4区）
29. Fu-Chao Chen; Xiao-Ya Shi; Peng Li; Jin-Guo Yang; Ben-Hong Zhou*. Stability of Butorphanol–Tropisetron Mixtures in 0.9% Sodium Chloride Injection for Patient-Controlled Analgesia Use. Medicine. 2015, 94(6):432.
30. Chen, Fuchao., Fang, Baoxia., Li, Peng., Zhu, Xuesong., Zhou, Benhong*., Physico-chemical stability of butorphanol-tramadol and butorphanol-fentanyl patient-controlled analgesia infusion solutions over 168 hours. Pharmazie. 2014, 69:585-588. （1.117,3区）
31. Qiu, Zhenpeng., Zhou, Benhong#*., Jin, Long., Yu, Honglian., Liu, Lijuan., Liu, Youyi., Qin, Chengchen., Xie, Shuixiang., Zhu, Fan., In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. Food and Chemical Toxicology, 2013, 59:428-437. （IF: 4.679,2区top）
32. 陈鹏,涂晶晶,李巧玲,周本宏*.肠道菌群对石榴皮鞣质的分解代谢作用研究.中草药,2019,50(14):3396-3402.
33. 周本宏*,李旷宇,姜姗,吴玥,兰昱.安石榴苷在Caco-2细胞模型的肠吸收机制[J].中国现代中药,2019,21(03),316-322.
34. 周本宏*,李妍,周梦宇.消炎抗菌片的抗菌活性及对福氏志贺氏菌的抗菌机制初步探讨[J].中国医院药学杂志,2018,38(23),2429-2433.
35. 周本宏*,陈鹏,涂杰,吴玥,刘刚.石榴皮鞣质对肾小球硬化大鼠内源性物质代谢的影响及代谢通路分析[J].中草药,2017,48(10):2072-2080.
36. 周本宏*,邱振鹏,易慧兰,周丁山,汪静,吴玥.鞣花鞣质肠道代谢物urolithins研究进展[J].中国中药杂志,2016,41(16):2986-2974.
37. 周静,周本宏*,涂杰,张婵,罗毅,刘刚.石榴皮提取物中鞣花酸和没食子酸在大鼠体内的药代动力学研究[J].中国医药导报,2015,12(3):19-23
38. 周本宏*,张红盼,郭敏,陈振华,王高华.补肾壮阳胶囊对小鼠认知功能障碍的改善作用及机制研究[J].中国医院药学杂志,2016,36(20):1739-1744
39. 松长青,周本宏*,易慧兰,等.石榴皮鞣质的抗菌活性及其对金黄色葡萄球菌的抗菌机制[J].中国医院药学杂志.2016,36(4):259-265
40. 周本宏*,周静,梁艺小,吴玥,罗毅,刘苗苗,刘刚.石榴皮鞣质改善大鼠肾纤维化作用研究[J],中草药,2014,45(11),1585-1590.
41. 涂杰,刘苗苗,吴玥,周本宏*.石榴皮鞣质对慢性肾小球肾炎大鼠内源性代谢物的影响[J],中国医院药学杂志,2015,35(8):673-678
42. 周本宏*,凃杰,金龙,吴玥,罗毅,刘刚,周静.石榴皮鞣质在大鼠体内的代谢产物分析[J],中国药学杂志,2014,49(10),821-824.
43. 周本宏*,周静,梁艺小,易慧兰,吴玥,刘刚.石榴皮鞣质对肾纤维化大鼠内源性代谢产物的影响[J],中国医院药学杂志,2014,34(23),2009-2013.
44. 周本宏*，周静,吴丽宁,涂杰,吴玥,刘刚.天麻-川穹对偏头痛模型大鼠尿液内源性物质代谢的影响[J],中国实验方剂学杂志,2014,20(3):104-108.
45. 周本宏*,汪静.鞣花酸缓解糖尿病小鼠肾损伤的抗氧化机制研究.中国药师,2016,19(12):2229-2233.
46. 陈鹏,吴玥,周本宏*.地榆鞣质改善D-型半乳糖致衰老大鼠抗氧化,抗炎作用的研究[J].中国药师,2018,21(04):562-565.
47. 曾茂林,周本宏*.石榴皮鞣质对膀胱癌T24细胞迁移侵袭能力的影响研究[J].中国药物警戒,2018,15(7):385-397.
48. 周梦宇,周本宏*,郭咸希.石榴皮鞣质作为天然抑菌剂的研究进展[J].中国药师,2018,21(11):2037-2040.
49. 周本宏*,曾茂林,周梦宇,邱振鹏,吴玥.石榴皮鞣质对膀胱癌T24细胞增殖及凋亡的影响[J].中国医院药学杂志,2018,38(20):2096-2100.
