Position: Professor
School/Academic Group: School of Pharmaceutical Sciences
Email: fzhang83@whu.edu.cn
Education：
2003.09 - 2007.09 School of Pharmacy, Jilin University，Bachelor
2007.09 - 2012.06 Institute of Microbiology, Chinese Academy of Sciences，Ph.D.
Working Experience：
2012.07 – 2013.03 Institute of Microbiology, Chinese Academy of Sciences，Assistant Researcher
2013.04 - 2014.04 Department of Chemistry, Faculty of Science, University of Manitoba，Postdoc
2014.05 - 2015.05 Department of Medicine, School of Medicine and Public Health, University of Wisconsin–Madison，Postdoc
2015.05 - 2021.05 Department of Medicine, School of Medicine and Public Health, University of Wisconsin–Madison， Assistant Researcher
2021.07 - now Wuhan University, Professor
Current Teaching Interests/Responsibilities:
Instrumental Analysis
Research Interests:
Development of Microbial-Derived Lead Compounds Targeting Drug-Resistant Bacteria
Publications：
1. Zhang, F.;# Zhao, M.;# Braun, D. R.; Ericksen, S. S.; Piotrowski, J. S.; Nelson, J.; Peng, J.; Ananiev, G. E.; Chanana, S.; Barns, K.; Fossen, J.; Sanchez, H.; Chevrette, M. G.; Guzei, I. A., Zhao, C.; Guo, L.; Tang, W.; Currie, C. R.; Rajski, S. R.; Audhya, A.; Andes, D. R.*; Bugni, T. S.* A marine microbiome antifungal targets urgent-threat drug-resistant fungi. Science 2020, 370, 974–978.
2. Zhao, M.;# Zhang, F.;# Zarnowski, R.; Barns, K.; Jones, R. Fossen, J.; Sanchez, H.; Rajski, S. R.; Audhya, A.; Bugni, T. S.*; Andes, D. R.* Turbinmicin inhibits Candida biofilm growth by disrupting fungal vesicle-mediated trafficking. J. Clin. Investig. 2021, 131, e145123.
3. Zhang, F.; Wyche, T. P.; Zhu, Y.; Braun, D. R.; Yan, J. –X.; Chanana, S.; Ge, Y.; Guzei, I. A.; Chevrette, M. G.; Currie, C. R.;, Thomas, M. G.; Rajski, S. R.; Bugni, T. S.* MS-derived isotopic fine structure reveals forazoline A as a thioketone-containing marine-derived natural product. Org. Lett.2020, 22, 1275–1279.
4. Zhang, F.; Braun, D. R.; Chanana, S.; Rajski, S. R.; Bugni, T. S.* Phallusialides A-E, pyrrole-derived alkaloids discovered from a marine-derived Micromonospora sp. bacterium using MS-based metabolomics approaches. J. Nat. Prod. 2019, 82, 3432–3439.
5. Zhang, F.; Braun, D. R.; Rajski, S. R.; DeMaria, D.; Bugni, T. S.* Enhypyrazinones A and B, pyrazinone natural products from a marine-derived myxobacterium Enhygromyxa sp. Mar. Drugs. 2019, 17, 698.
6. Zhang, F.; Braun, D. R.; Ananiev, G. E.; Hoffmann, F. M.; Tsai, I. W.; Rajski, S. R.; Bugni, T. S.* Biemamides A-E, inhibitors of the TGF-β pathway that block the epithelial to mesenchymal transition. Org. Lett. 2018, 20, 5529–5532.
7. Zhang, F.; Barns, K.; Hoffmann, F. M.; Braun, D. R.; Andes, D. R.; Bugni, T. S.* Thalassosamide, a siderophore discovered from the marine-derived bacterium Thalassospira profundimaris. J. Nat. Prod.2017, 80, 2551–2555.
8. Zhang, F.; Adnani, N.; Vazquez-Rivera, E.; Braun, D. R.; Tonelli, M.; Andes, D. R.; Bugni, T. S.* Application of 3D NMR for structure determination of peptide natural products. J. Org. Chem. 2015, 80, 8713–8719.
9. Ren, J.;# Zhang, F.;# Liu, X.; Li, L.; Liu, G.; Liu, X.; Che, Y.* Neoectrolide A, a new oxaphenalenone spiroketal from the fungus Neonectria sp. Org. Lett. 2012, 24, 6226–6229.
10. Zhang, F.; Li, L.; Niu, S.; Si, Y.; Guo, L.; Jiang, X.; Che, Y.* A thiopyranchromenone and other chromone derivatives from an endolichenic fungus, Preussia africana. J. Nat. Prod. 2012, 75, 230–237.
11. Zhang, F.;# Ding, G.;# Li, L.; Cai, X.; Si, Y.; Guo, L.; Che, Y.* Isolation, antimicrobial activity, and absolute configuration of the furylidene tetronic acid core of pestalotic acids A–G. Org. Biomol. Chem. 2012, 10, 5307–5314.
12. Ding, G.;# Zhang, F.;# Chen, H.; Guo, L.; Zou, Z.; Che, Y.* Pestaloquinols A and B, isoprenylated epoxyquinols from Pestalotiopsis sp. J. Nat. Prod. 2011, 74, 286–291.
13. Zhang, F.; Liu, S.; Lu, X.; Guo, L.; Zhang, H.; Che, Y.* Allenyl and allkynyl phenyl ethers from the endolichenic fungus Neurospora terricola. J. Nat. Prod. 2009, 72, 1782–1785.
14. Schorn, M. A.; Stefan, V.; [et al, including Zhang, F.] A community resource for paired genomic and metabolomic data mining. Nat Chem Biol. 2021, 17, 363–368.
15. Vinnik, V.; Zhang, F.; Park, H.; Cook, T.; Throckmorton, K.; Pfleger, B.; Bugni, T.; Thomas, M.* Structural and biosynthetic analysis of the fabrubactins, unusual siderophores from Agrobacterium fabrum strain C58. ACS Chem. Biol. 2021, 16, 125–135.
16. Chanana, S.; Thomas, C. S.; Zhang, F.; Rajski, S. R.; Bugni T. S.* hcapca: Automated Hierarchical Clustering and Principal Component Analysis of large metabolomic datasets in R. Metabolites 2020, 10, 297.
17. Chevrette, M. G.; Carlson, C. M.; Ortega, H. E.; Thomas, C.; Ananiev, G. E.; Barns, K. J.; Book, A. J.; Cagnazzo, J.; Carlos, C.; Flanigan, W.; Grubbs, K. J.; Horn, H. A.; Hoffmann, F. M.; Klassen, J. L.; Knack, J. J.; Lewin, G. R.; McDonald, B. R.; Muller, L.; Melo, W. G. P.; Pinto-Tomás, A. A.; Schmitz, A.; Wendt-Pienkowski, E.; Wildman, S.; Zhao, M.; Zhang, F.; Bugni, T. S.; Andes, D. R.; Pupo, M. T.; Currie C. R.* The antimicrobial potential of Streptomyces from insect microbiomes. Nat. Commun.2019, 10, 516.
18. Adnani, N.; Chevrette, M. G.; Adibhatla, S. N.; Zhang, F.; Yu, Q.; Braun, D. R.; Nelson, J.; Simpkins, S. W.; McDonald, B. R.; Myers, C. L.; Piotrowski, J. S.; Thompson, C. J.; Currie, C. R.; Li, L.; Rajski, S. R.; Bugni, T. S.* Coculture of marine invertebrate-associated bacteria and interdisciplinary technologies enable biosynthesis and discovery of a new antibiotic, keyicin. ACS Chem. Biol. 2017, 12, 3093–3102.
19. Xu, X.; Liu, L.; Zhang, F.; Wang, W.; Li, J.; Guo, L.; Che, Y.*; Liu, G.* Identification of the first diphenyl ether gene cluster for pestheic acid biosynthesis in plant endophyte Pestalotiopsis fici. ChemBioChem 2014, 15, 284–292.
20. Li, E.; Zhang, F.; Niu, S.; Liu, X.; Liu, G.; Che, Y.* A spiro[chroman-3,7'-isochromene]- 4,6'(8H')-dione from the Cordyceps-Colonizing fungus Fimetariella sp. Org. Lett. 2012, 14, 3320–3323.
