Position: Professor
School/Academic Group: School of Pharmaceutical Sciences
Email: jqyu@whu.edu.cn
Education：
2002-2005 College of Life Sciences, Wuhan University，Ph.D.
Professional Memberships and/or Notable Appointments:
Hubei Society of Botany, Member of the Standing Council
Wuhan Society of Biophysics, Member of the Standing Council
Working Experience：
1998 – 2005 Renmin Hospital of Wuhan University
2008 - 2009 University of Waterloo，Postdoc
2006 - now Wuhan University, Professor
Research Interests:
Pharmacological mechanisms of bioactive natural products; Molecular mechanisms of antineoplastic drug action; Innovative pharmaceutical formulations and delivery systems
Publications：
1. Cai YS (#), Wu Z (#), Zheng XQ, Wang C, Wang JR, Zhang XX, Qiu G, Zhu K, Cao S, Yu J* (2020). Spiroalanpyrroids A and B, sesquiterpene alkaloids with a unique spiro- eudesmanolide–pyrrolizidine skeleton from Inula helenium. Organic Chemistry Frontiers 7: 303–309.
2. Wu Z (#), Cai YS (#), Yuan R, Wan Q, Xiao D, Lei J*, Yu J* (2020). Bioactive pterocarpans from Trigonella foenum-graecum L. Food Chemistry 313: 126092-126092.
3. Cai YS(#), Wu Z(#), Wang JR, Zheng XQ, Xu J, Qiu G, Yu J* (2019). Spiroalanfurantones A–D, four eudesmanolide–furan sesquiterpene adducts with a pentacyclic 6/6/5/5/5 skeleton from Inula helenium. Organic Letters 21：9478-9482.
4. Xie Z (#), Wei Y (#), Xu J, Lei J, Yu J* (2019). Alkaloids from Piper nigrum Synergistically Enhanced the Effect of Paclitaxel against Paclitaxel- Resistant Cervical Cancer Cells through the Downregulation of Mcl-1. Journal of Agricultural and Food Chemistry 67: 5159−5168.
5. Xie Z, Guo Z, Lei J, Yu J* (2019). Scutellarin synergistically enhances cisplatin effect against ovarian cancer cells through enhancing the ability of cisplatin binding to DNA. European Journal of Pharmacology 844: 9–16.
6. Guo Z#, Xu J#, Xia J, Wu Z, Lei J, Yu J* (2019). Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L. Journal of Pharmacy and Pharmacology 71: 1162–1171.
7. Wu Z #, Xia J #, Guo Z, Lei J, Yu J* (2019). Biological activities of the extracts and compounds from the bark of Pterocarya hupehensis skan. Natural Product Research doi.org/10.1080/14786419.2019.1643857.
8. Xie Z, Guo Z, Wang Y, Lei J, Yu J* (2018). Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy. Phytotherapy Research 32(1): 2256–2263.
9. Xia J #, Yang C #, Wang Y, Yang Y, Yu J*(2017). Antioxidant and antiproliferative activities of the leaf extracts from Trapa bispinosa and active components. South African Journal of Botany 113: 377–381.
10. Yang Y, Chen H, Lei J, Yu J* (2016). Biological activity of extracts and active compounds isolated from Siegesbeckia orientalis L. Industrial Crops and Products 94: 288–293.
11. Lei JC#, Yang CX#，Yang Y, Zhang W, Yu J* (2015). Antioxidant and antitumour activities of extracts from Patrinia villosa and its active constituents. Journal of Functional Foods 16: 289–294.
12. Yu J*, Bao W, Lei J (2013). Emodin regulates apoptotic pathway in human liver cancer cells. Phytotherapy Research 27(2): 251–257.
13. Ding C, Zhang W, Li J, Lei J, Yu J*(2013). Cytotoxic constituents of ethyl acetate fraction fromDianthus superbus. Natural Product Research 27: 1691–1694.
14. Luo T#, Yu J*, Nguyen J#, Wang CR, Bristow RG, Jaffray DA, Zhou XZ, Lu KP, Lu QB* (2012). Electron transfer-based combination therapy of cisplatin with tetramethyl-p-phenylenediamine for ovarian, cervical, and lung cancers. Proc. Natl. Acad. Sci. USA (PNAS)109：10175–10180.
15. Yu J*, Yin Y, Lei J, Zhang X, Chen W, Ding C, Wu S, He X, Liu Y, Zou G (2012). Activation of apoptosis by ethyl acetate fraction of ethanol extract of Dianthus superbus in HepG2 cell line. Cancer Epidemiology 36: e40–e45.
16. Lei J, Yu J*, Yin Y, Liu Y, Zou G (2012). Alantolactone induces activation of apoptosis in human hepatoma cells. Food and Chemical Toxicology 50: 3313–3319.
17. Yu J*, Lei J, Zhang X, Yu H, Tian D, Liao Z, Zou G (2011). Anticancer, antioxidant and antimicrobial activities of the essential oil of Lycopus lucidus Turcz. var. hirtus Regel. Food Chemistry 126: 1593–1598.
18. Lei J, Yu J*, Yu H, Liao Z. Composition, cytotoxicity and antimicrobial activity of essential oil from Dictamnus dasycarpus. Food Chemistry, 2008, 107: 1205–1209.
19. Yu J*, Liu H, Tian D, Liu Y, Lei J, Zou G (2007). Changes in mitochondrial membrane potential and reactive oxygen species during wogonin-induced cell death in human hepatoma cells. Hepatology Research 37: 68–76.
20. Yu J*, Liu H, Lei J, Tan W, Hu X, Zou G (2007). Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. Phytotherapy Research 21: 817–822.
21. Yu J*, Liao Z, Lei J, Hu X (2007). Antioxidant and cytotoxic activities of various fractions of ethanol extract of Dianthus superbus. Food Chemistry 104: 1215-1219.
22. Yu J*, Liao Z, Cai X, Lei J, Zou G (2007). Composition, antimicrobial activity and cytotoxicity of essential oils from Aristolochia mollissima. Environmental Toxicology and Pharmacology 23: 162–167.
