Position: Professor
School/Academic Group: School of Pharmaceutical Sciences
Email: xia_yao@whu.edu.cn
Education：
2010.09–2014.06: Shandong University, Bachelor
2014.09–2019.06: . Tsinghua University, Ph.D
Working Experience：
2019.09–2023.01: Princeton University of Molecular Biology, Postdoc
2023.02–Present: Wuhan University, School of Pharmaceutical Sciences, Professor
Research Interests:
Mechanistic Analysis of Ion Channel Drug Regulation and Novel Drug Development
Publications：
1. Xia Yao#, Shuai Gao#, Jixin Wang, Zhangqiang Li, Jian Huang, Yan Wang, Zhifei Wang, Jiaofeng Chen, Xiao Fan, Weipeng Wang, Xueqin Jin, Xiaojing Pan, Yong Yu, Armando Lagrutta, and Nieng Yan, Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels. Cell, 185，4801-4810 (2022)
2. Shuai Gao#, Xia Yao#, Nieng Yan, Structure of human Cav2.2 channel blocked by the painkiller ziconotide. Nature, 596, 143-147 (2021)
3. Xia Yao, Yan Wang, Zhifei Wang, Xiao Fan, Di Wu, Jian Huang, Alexander Mueller, Sarah Gao, Miaohui Hu, Carol V. Robinson, Yong Yu, Shuai Gao, Nieng Yan, Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments. Nature Communications, 13, 7358 (2022)
4. Xia Yao#*, Shuai Gao#, Nieng Yan, Structural basis for pore blockade of human voltage-gated calcium channel Cav1.3 by motion sickness drug cinnarizine. Cell Research, 32, 946-948 (2022) (also as corresponding author)
5. Xia Yao#, Xiao Fan#, Nieng Yan, Cryo-EM analysis of a membrane protein embedded in the liposome. PNAS, 117, 18497-18503 (2020)
6. Hongwu Qian#, Xuelan Wu#, Ximing Du#, Xia Yao, Xin Zhao, Joyce Lee, Hongyuan Yang, Nieng Yan, Structural basis of low-pH-dependent lysosomal cholesterol egress by NPC1 and NPC2. Cell, 182, 98–111 (2020)
7. Hongwu Qian#, Xin Zhao#, Renhong Yan#, Xia Yao, Shuai Gao, Xue Sun, Ximing Du, Hongyuan Yang, Catherine CL Wong, and Nieng Yan, Structural basis for catalysis and substrate specificity of human ACAT1. Nature, 581, 333- 338 (2020)
8. Xia Yao#, Xiuyun Sun#, Shuyu. Jin, Ling Yang, Hongjiang Xu, Yu Rao, Discovery of 4-aminoquinoline-3- carboxamide derivatives as potent reversible bruton’s tyrosine kinase inhibitors for the treatment of rheumatoid arthritis. Journal of Medicinal Chemistry, 62, 6561–6574 (2019)
9. Xiuyun Sun#, Jun Wang#, Xia Yao#, Wen Zheng, Yang Mao, Tianlong Lan, Liguo Wang, Yonghui Sun, Xinyi Zhang, Qiuye Zhao, Jiangguo Zhao, Ruiping, Xiao, Xiuqin Zhang, Guangju Ji, Yu Rao, A chemical approach for global protein knockdown from mice to non-human primates. Cell Discovery, 5:10 (2019)
