Position: Professor
School.Academic Group: School of Pharmaceutical Sciences
Email: xuyidan70188@whu.edu.cn
Education：
2000.09–2005.06, Wuhan University of Medicine, Bachelor
2005.09–2010.06, Wuhan University of Basic Medical Sciences, Ph.D
Professional Memberships and.or Notable Appointments:
Youth Committee of Analytical Pharmacology, Chinese Pharmacological Society, Director
Youth Committee, Chinese Society of Toxicology, Standing Committee Member
Committee on Environment and Developmental Diseases, Chinese Environmental Mutagen Society, Standing Committee Member
Specialty Committee of Biochemical and Molecular Pharmacology, Chinese Pharmacological Society, Committee Member
Youth Committee of Teaching and Popular Science, Chinese Pharmacological Society, Committee Member
Committee on Environment and Reproductive Health, Hubei Reproductive Health Association, Vice Chair
Hubei Pharmacological Society, Council Member
Hubei Society of Toxicology, Council Member
Wuhan Pharmacological Society, Vice President
Working Experience：
2010.07–2012.06 Wuhan University of Life Sciences, Postdoc
2010.07–2021.12 Wuhan University of Basic Medical Sciences, Lecturer, Associate Professor
2016.01–2017.01 University of Pittsburgh, Visiting Scholar
2022.01–now Wuhan University, School of Pharmaceutical Sciences, Professor
Current Teaching Interests./Responsibilities:
Pharmacology
Research Interests:
Developmental Toxicology and Drug Target Discovery; Focus on Intrauterine Programming Mechanisms, Prevention Targets, and Novel Therapeutics for Drug-Related Fetal Diseases
Publications：
1. Wang TT#, Chen BD#, Luo MC, Xie LL, Lu MX, Zhang S, Wei LY, Zhou XL, Yao BZ, Wang H, Xu D*. Microbiota-Indole 3-Propionic Acid-Brain Axis Mediates Abnormal Synaptic Pruning of Hippocampal Microglia and Susceptibility to ASD in IUGR Offspring. Microbiome. 2023;11(1):245.
2. Luo MC#, Yi YW#, Huang SQ, Dai SY, Xie LL, Liu KX, Zhang S, Jiang T, Wang TT, Yao BZ, Wang H, Xu D*. Gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effects. Acta Pharm Sin B. 2023;13(9):3708-3727.
3. Wang TT#, Zhang S#, Luo MC, Lu MX, Wei LY, Zhou XL, Wang H, Xu D*. Prenatal caffeine exposed-offspring develop autism-like behaviors under a high-fat diet via the gut microbiota-IL-17A-brain axis. Ecotox Environ Safe. 2024;269:115797.
4. Lu MX#, Dai SY#, Dai GL#, Wang TT, Zhang S, Wei LY, Luo MC, Zhou XL, Wang H, Xu D*. Dexamethasone induces developmental axon damage in the offspring hippocampus by activating miR-210-3p/miR-362-5p to target the aberrant expression of Sonic Hedgehog. Biochem Pharmacol. 2024;226:116330.
5. Zhao XQ#, Xiao H#, Li X, Zhu L, Peng Y, Chen H, Chen L, Xu D*, Wang H*. Multi-organ developmental toxicity and its characteristics in fetal mice induced by dexamethasone at different doses, stages, and courses during pregnancy. Arch Toxicol. 2024;98(6):1891-1908.
6. Zhang S#, Wang TT, Feng Y, Li F, Qu AJ, Guan XC, Wang H*, Xu D*. Pregnenolone 16α-carbonitrile Negatively Regulates Hippocampal Cytochrome P450 Enzymes and Ameliorates Phenytoin-induced Hippocampal Neurotoxicity. J Pharm Anal. 2023;13(12):1510-1525.
7. Wei LY, Wang TT, Luo MC, Zhang S, Lu MX, Zhou XL, Cheng XL, Wang H, Xu D*. A "Toxic Window" Study on the Hippocampal Development of Mice Offspring Exposed to Azithromycin at Different Doses, Courses, and Time During Pregnancy. Chem-Biol Interact. 2023;110814.
8. Huang J#, Wu TC#, Li YT, Zhang YZ, Yu XJ*, Xu D*, Wang H*. Toxic effect window of ovarian development in female offspring mice induced by prenatal prednisone exposure with different doses and time. J Ovarian Res. 2023;16(1):71.
9. Qin JX#, Yao BZ#, Xie LL, Wang TT, Zhang S, Luo MC, Wang H, Xu D*, Peng BW*. Impact of prenatal amoxicillin exposure on hippocampal development deficiency. Neuropharmacology. 2023;223:109331.
10. Zhang S#, Hu SW#, Dong WT#, Huang SQ, Jiao ZX, Hu ZW, Dai SY, Yi YW, Gong XH, Li K, Wang H*, Xu D*. Prenatal dexamethasone exposure induces anxiety- and depressive-like behavior of male offspring rats through intrauterine programming of the activation of NRG1-ErbB4 signaling in hippocampal PV interneurons. Cell Biol Toxicol. 2023;39(3):657-678.
11. Jiang T#, Hu SW, Dai SY, Yi YW, Wang TT, Li XF, Luo MC, Li K, Chen LB, Wang H, Xu D*. Programming changes of hippocampal miR-134-5p/SOX2 signal mediate the susceptibility to depression in prenatal dexamethasone exposed-female offspring. Cell Biol Toxicol. 2022;38(1):69-86.
12. Ge CY#, Xu D#, Yu PX, Fang M, Guo JJ, Xu D, Qiao Y, Chen SJ, Zhang YZ*, Wang H*. P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss. BMC Medicine. 2021;19(1):311.
13. Gong XH#, Dai SY, Wang TT, Zhang JZ#, Fan GL, Luo MC, Yi YW, Wang H, Lu DX*, Xu D*. MiR-17-5p/FOXL2/CDKN1B signal programming in oocytes mediates transgenerational inheritance of diminished ovarian reserve in female offspring rats induced by prenatal dexamethasone exposure. Cell Biol Toxicol. 2021 Sep 19. doi: 10.1007/s10565-021-09645-6.
14. Gong XH#, Zhang JZ#, Ge CY#, Yi YWa, Dai SY, Fan GL, Li CR, Zhang YZ, Wang H*, Xu D*. miRNA320a-3p/RUNX2 signal programming mediates the transgenerational inheritance of inhibited ovarian estrogen synthesis in female offspring rats induced by prenatal dexamethasone exposure. Pharmacol Res. 2021 Mar;165:105435. doi: 10.1016/j.phrs.2021.105435.
15. Chen YW#, Xu D#, Xia X, Chen GH, Xiao H, Chen LB, Wang H*. Sex difference in adrenal developmental toxicity induced by dexamethasone and its intrauterine programming mechanism. Pharmacol Res. 2021;174:105942.
16. Hu S#, Yi Y#, Jiang T, Jiao Z, Dai S, Gong X, Li K, Wang H, Xu D*. Intrauterine RAS programming alteration-mediated susceptibility and heritability of temporal lobe epilepsy in male offspring rats induced by prenatal dexamethasone exposure. Arch Toxicol. 2020;94(9):3201-3215.
17. Jiang T#, Dai S, Yi Y, Liu Y, Zhang S, Luo M, Wang H*, Xu D*. The combination of hprt and gapdh is the best compound reference genes in the fetal rat hippocampus. Dev Neurobiol. 2020;80(7-8):229-238.
18. Pei Y#, Jiao Z, Dong W, Pei L, He X, Wang H, Xu D*. Excitotoxicity and compensatory upregulation of GAD67 in fetal rat hippocampus caused by prenatal nicotine exposure are associated with inhibition of the BDNF pathway. Food Chem Toxicol. 2019;S0278-6915(18):30801-30809.
19. Ni Y#, Xu D#, Lv F, Wan Y, Fan G, Zou W, Chen Y, Pei LG, Yang J*, Wang H*. Prenatal ethanol exposure induces susceptibility to premature ovarian insufficiency. J Endocrinol. 2019; 243:1-16.
20. Hu S#, Xia L#, Luo H, Xu Y, Yu H, Xu D*, Wang H*. Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBPα-SIRT1 pathway. Toxicology. 2019;417:23-34.
21. Huang SQ#, Dong WT, Jiao ZX, Liu J, Li K, Wang H, Xu D*. Prenatal dexamethasone exposure induced alterations in neurobehavior and hippocampal glutamatergic system balance in female rat offspring. Toxicol Sci. 2019; 171(2): 369-384.
22. Hu S#, Qin J#, Zhou J, Magdalou J, Chen L, Xu D*, Wang H*. Glucocorticoid programming mechanism for hypercholesterolemia in prenatal ethanol-exposed adult offspring rats. Toxicol Appl Pharmacol. 2019;375:46-56.
