Position: Professor
School/Academic Group: School of Pharmaceutical Sciences
Email: lianrong@whu.edu.cn
Education：
1999 - 2003 School of Life Sciences, Shandong University，Bachelor
2003 - 2008 School of Life Sciences and Biotechnology, Shanghai Jiao Tong University，Ph.D.
2006 - 2008 Department of Biological Engineering, Massachusetts Institute of Technology，Visiting Ph.D.
Professional Memberships and/or Notable Appointments:
Microbiological Research, Associate Editor
Frontiers in Microbiology, Guest Editor
Working Experience：
2008 - 2011 Department of Biological Engineering, Massachusetts Institute of Technology，Postdoc
2011 - now School of Pharmaceutical Sciences, Wuhan University, Professor
Research Interests:
Genomic phosphorothioate modification and synthetic biology; Epigenetic and biomedical applications
Publications：
1. Xiaolin Xiong, Geng Wu, Yue Wei, Liqiong Liu, Yubing Zhang, Rui Su, Xianyue Jiang, Mengxue Li, Haiyan Gao, Xihao Tian, Yizhou Zhang, Li Hu, Si Chen, You Tang, Susu Jiang, Ruolin Huang, Zhiqiang Li, Yunfu Wang, Zixin Deng, Jiawei Wang, Peter C. Dedon, Shi Chen, Lianrong Wang*. SspABCD-SspE is a phosphorothioation-sensing bacterial defense system with broad antiphage activities, Nature Microbiology, 2020, July, 5: 917-928. DOI: 10.1038/s41564-020-0700-6.
2. Dan Wu#, Yaqian Tang, Siwei Chen, Yue He, Xiaofei Chang, Wenzhong Zheng, Zixin Deng, Zhiqiang Li, Lianrong Wang*, Geng Wu* & Shi Chen*. The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex. Nature Catalysis. 2022, December, Volume 5, 1131–1144.
3. Xiaolin Wu#, Bo Cao#, Patricia Aquino, Tsu-Pei Chiu, Chao Chen, Susu Jiang, Zixin Deng, Shi Chen, Remo Rohs, Lianrong Wang*, James E Galagan*, Peter C Dedon*. Epigenetic Competition Reveals Density-Dependent Regulation and Target Site Plasticity of Phosphorothioate Epigenetics in Bacteria. Proc Natl Acad Sci U S A. 2020, June, 117 (25):14322-14330. DOI: 10.1073/pnas.2002933117.
4. Xuan Zou#, Xiaohong Xiao, Ziran Mo, Yashi Ge, Xing Jiang, Ruolin Huang, Mengxue Li, Zixin Deng, Shi Chen*, Lianrong Wang*, Sang Yup Lee*. Systematic strategies for developing phage resistant Escherichia coli strains. Nature Communications, 2022, 13: 4491.
5. Haiyan Gao, Xinqi Gong, Jinchuan Zhou , Yubing Zhang, Jinsong Duan, Yue Wei, Liuqing Chen, Zixin Deng, Jiawei Wang, Shi Chen*, Geng Wu *, Lianrong Wang*. Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE. Nature Communications, 2022, November, 13:6773.
6. Ming-Yu Wu#, Luojia Chen, Qingrong Chen, Rui Hu, Xiaoyu Xu, Yifei Wang, Jie Li, Shun Feng, Changjiang Dong, Xiao-Lian Zhang, Zhiqiang Li, Lianrong Wang,* Shi Chen,* and Meijia Gu*. Engineered Phage with Aggregation-Induced Emission Photosensitizer in Cocktail Therapy against Sepsis. Advanced Materials. 2023, 35, 2208578, DOI: 10.1002/adma.202208578.
7. Ming-Yu Wu#, Xiaoyu Xu#, Rui Hu#, Qingrong Chen, Luojia Chen, Yuncong Yuan, Jie Li, Li Zhou, Shun Feng, Lianrong Wang*, Shi Chen*, Meijia Gu*. A Membrane-Targeted Photosensitizer Prevents Drug Resistance and Induces Immune Response in Treating Candidiasis. Advanced Science. 2023; e2207736. doi: 10.1002/advs.202207736.
8. Yue Wei#, Qinqin Huang, Xihao Tian, Mingmin Zhang, Junkai He, Xingxiang Chen, Chao Chen, Zixin Deng, Zhiqiang Li, Shi Chen, and Lianrong Wang*, Single-molecule optical mapping of the distribution of DNA phosphorothioate epigenetics. Nucleic Acids Research, 2021, Doi: 10.1093/nar/gkab169.
9. Ming-Yu Wu, Meijia Gu, Jong-Kai Leung, Xinmei Li, Yuncong Yuan, Chao Shen, Lianrong Wang*, Engui Zhao*, Sijie Chen*. A Membrane-Targeting Photosensitizer with Aggregation-Induced Emission Characteristics for Highly Efficient Photodynamic Combat of Human Coronaviruses. Small, 2021, June, https://doi.org/10.1002/smll.202101770.
10. Bo Cao#, Chao Chen#, Michael S. DeMott#, Qiuxiang Cheng, Tyson A. Clark, Xiaolin Xiong, Xiaoqing Zheng, Vincent Butty, Stuart S. Levine, George Yuan, Matthew Boitano, Khai Luong, Yi Song, Xiufen Zhou, Zixin Deng, Stephen W. Turner, Jonas Korlach, Delin You*, Lianrong Wang*, Shi Chen*, Peter C. Dedon. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature Communications. 2014, 5: 3951.
11. Wenzhong Zheng#, Kexin Wang#, Yachen Wu#, Ge Yan, Chi Zhang, Zhiqiang Li, Lianrong Wang*, Shi Chen*. C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α. Theranostics. : 2022, Oct, 17, , Vol. 12, Issue 17.
12. You Tang#, Yue Hong, Li Liu, Xuan Du, Yaqi Ren, Susu Jiang, Wanjing Liu, Chen Chao, Zixin Deng, Lianrong Wang*, Shi Chen*. Involvement of the DNA Phosphorothioation System in TorR Binding and Anaerobic TMAO Respiration in Salmonella enterica. mBio, 2022, April 14, Vol. 13, No. 3.
13. He W#, Gao H#, Wu D, Jiang S, Huang W, Chen C, Deng Z, Xiong L, Wu G*, Wang L*. Structural and Functional Analysis of DndE Involved in DNA Phosphorothioation in the Haloalkaliphilic Archaea Natronorubrum bangense JCM10635. mBio. 2022 Apr 14:e0071622. doi: 10.1128/mbio.00716-22.
14. Pengqing Nie#, Zhiqiang Li#, Yimeng Wang, Yubing Zhang, Mengna Zhao, Jie Luo, Shiming Du, Zixin Deng, Jincao Chen, Yunfu Wang, Shi Chen, Lianrong Wang*. Gut microbiome interventions in human health and diseases. Medicinal Research Reviews, 2019 Apr 17. doi: 10.1002/med.21584.
15. Yajie Wang# , Zhikang Miao# , Chang Xu, Ying Cai, Yuting Yang, Yue Hu, Mengna Zhao, Yue Shao, Zhiqiang Li, Jincao Chen, Shi Chen*, Lianrong Wang*. Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats. Cell Death & Disease, 2023 May 13;14(5):325. doi: 10.1038/s41419-023-05846-5.
16. Meijia Gu#,*, Luojia Chen#, Rui Hu, Qingrong Chen, Jianbo Liu*, Lianrong Wang*, Shi Chen*. Aggregation-induced emission: recent applications in infectious diseases. SCIENCE CHINA Chemistry, 2023 Oct 24. doi.org/10.1007/s11426-023-1825-7.
17. Lianrong Wang#, Shi Chen#, Tiegang Xu, Koli Taghizadeh, John S Wishnok, Xiufen Zhou, Delin You, Zixin Deng*, Peter C Dedon*. Phosphorothioation of DNA in bacteria by dnd genes. Nature Chemical Biology. 2007;3(11):709-10.
18.Lianrong Wang, Shi Chen*, Kevin L. Vergin, Stephen J. Giovannoni, Simon W. Chan, Michael S. DeMott, Koli Taghizadehe, Otto X. Cordero, Michael Cutler, Sonia Timberlake, Eric J. Alm, Martin F. Polz, Jarone Pinhassi, Zixin Deng, Peter C. Dedon*. DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci USA. 2011; 108(7):2963-8.
