Position: Professor

School/Academic Group: School of Pharmaceutical Sciences

Email: thui@whu.edu.cn

Education：

2009.09 - 2013.06  School of Pharmaceutical Sciences, Wuhan University，Bachelor

2013.09 - 2018.06  School of Pharmaceutical Sciences, Wuhan University，Ph.D.        

Working Experience：

2018.10 - 2022.08  University of Tokyo，JSPS Research Fellow

2022.08 - 2023.02  University of Tokyo，Project Researcher

2023.02 - now   Wuhan University, Professor

Current Teaching Interests/Responsibilities:

Synthetic biology

Research Interests:

Synthetic biology-driven biosynthesis of bioactive natural products; Mechanistic investigation and engineering of enzymatic catalysis

Publications：

1. Hui Tao^#; Lukas Lauterbach^#; Guangkai Bian^#; Rong Chen^#; Anwei Hou^#; Takahiro Mori^#; Shu Cheng; Ben Hu; Li Lu; Xin Mu; Min Li; Naruhiko Adachi; Masato Kawasaki; Toshio Moriya; Toshiya Senda; Xinghuan Wang; Zixin Deng; Ikuro Abe^*; Jeroen S Dickschat^*; Tiangang Liu^*. Discovery of non-squalene triterpenes. Nature, 2022, 606(7913): 414-419.

2. Hui Tao^#, Richiro Uhimaru^#,*, Takayoshi Awakawa, Takahiro Mori, Ikuro Abe*; Stereoselectivity and substrate specificity of the Fe (II)/α-ketoglutarate-dependent oxygenase TqaL. Journal of the American Chemical Society, 2022, 144(47): 21512-21520.

3. Hui Tao^#; Takahiro Mori^#,*; Heping Chen; Shuang Lyu; Akihito Nonoyama; Shoukou Lee; Ikuro Abe^* ; Molecular insights into the unusually promiscuous and catalytically versatile Fe (II)/α-ketoglutarate-dependent oxygenase SptF, Nature Communications, 2022, 13(95).

4. Hui Tao; Takahiro Mori; Xingxing Wei; Yudai Matsuda^*; Ikuro Abe^*; One polyketide synthase, two distinct products: trans-acting enzyme-controlled product divergence in calbistrin biosynthesis, Angewandte Chemie International Edition, 2021, 60(16): 8851-8858.

5. Hui Tao; Ikuro Abe^*; Harnessing Fe(II)/α-ketoglutarate-dependent oxygenases for structural diversification of fungal meroterpenoids. Current Opinion in Biotechnology, 2022, 77: 102763.

6. Hui Tao; Ikuro Abe^*; Enzymology and biosynthesis of the orsellinic acid derived medicinal meroterpenoids, Current Opinion in Biotechnology, 2021, 69:52-59.

7. Hui Tao^*; Ikuro Abe^*; Oxidative modification of free-standing amino acids by Fe (II)/αKG-dependent oxygenases. Engineering Microbiology, 2022: 100062.

8. Ziheng An^#; Hui Tao^#; Yong Wang; Bingqing Xia; Yang Zou; Shuai Fu; Fang Fang; Xiao Sun; Renqiong Huang; Yao Xia; Zixin Deng; Ran Liu^*; Tiangang Liu^*; Increasing the heterologous production of spinosad in Streptomyces albusJ1074 by regulating biosynthesis of its polyketide skeleton, Synthetic and Systems Biotechnology, 2021, 6(4): 292-301.

9. Hui Tao^#; Yuchen Zhang^#; Zixin Deng; Tiangang Liu^*; Strategies for enhancing the yield of the potent insecticide spinosad in actinomycetes, Biotechnology Journal, 2019, 14(1).

10. Hui Tao; Yuchen Zhang; Xiaoying Cao; Zixin Deng; Tiangang Liu^*; Absolute quantification of proteins in the fatty acid biosynthetic pathway using protein standard absolute quantification, Synthetic and Systems Biotechnology, 2016, 1(3): 150-157.

11. Hui Tao; Daoyi Guo; Yuchen Zhang; Zixin Deng; Tiangang Liu^*; Metabolic engineering of microbes for branched-chain biodiesel production with low-temperature property, Biotechnology for Biofuels, 2015, 8(92).

12. Takahiro Mori^#,*; Ziheng Yu^#; Hui Tao; Ikuro Abe^* ; Rational engineering of the nonheme iron-and 2-oxoglutarate-dependent oxygenase SptF, Organic Letters, 2022, 24(8): 1737-1741.

13. Tongxuan Bai^#; Yudai Matsuda^#,* ; Hui Tao; Takahiro Mori; Yonghui Zhang; Ikuro Abe^* ; Structural diversification of andiconin-derived natural products by α-ketoglutarate-dependent dioxygenases, Organic Letters, 2020, 22(11): 4311-4315.

14. Gao-Yi Tan; Kunhua Deng; Xinhua Liu; Hui Tao; Yingying Chang; Jia Chen; Kai Chen; Zhi Sheng; Zixin Deng; Tiangang Liu^*; Heterologous biosynthesis of spinosad: an omics-guided large polyketide synthase gene cluster reconstitution in streptomyces, ACS Synthetic Biology, 2017, 6(6): 995-1005.

15. Guangkai Bian; Yujie Yuan; Hui Tao; Xiaofei Shi; Xiaofang Zhong; Yichao Han; Shuai Fu; Chengxiang Fang; Zixin Deng; Tiangang Liu^* ; Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6, Biotechnology Journal, 2017, 12(4).