Position: Professor
School/Academic Group: School of Pharmaceutical Sciences
Email: wanyi-tai@whu.edu.cn
Education：
2000.09 - 2004.07 China Pharmaceutical University, Bachelor of Science
2004.09 - 2007.07 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Master of Science
2007.08 - 2012.08 University of Missouri-Kansas City (USA), Ph.D.
Working Experience：
2012.09 - 2013.11 University of North Carolina at Chapel Hill (USA), Department of Biomedical Engineering, Postdoc
2013.12 - 2018.12 University of Washington (USA), Department of Bioengineering, Postdoc
2019.02 - 2020.11 Wuhan University, School of Pharmaceutical Sciences, Specially Appointed Researcher
2020.12 - now Wuhan University, School of Pharmaceutical Sciences, Professor
Current Teaching Interests/Responsibilities:
Fundamentals of Pharmaceutical Engineering
Research Interests:
Pharmaceutics, antibody engineering, biomacromolecule drug delivery
Publications：
1. Yan Zheng, Wanyi Tai*. “Insight into the siRNA transmembrane delivery - from cholesterol conjugating to tagging.” WIREs Nanomed. Nanobiotechnol. 2019, e1606
2. Wanyi Tai*. Current aspects of siRNA bioconjugate for in vitro and in vivo delivery. Molecules 2019, 24(12), 2211
3. Wanyi Tai*. Chemical Modulation of siRNA lipophilicity for efficient delivery. Journal of Controlled Release 2019, 307, 98-107.
4. Wanyi Tai#, Pengfei Zhao#, Xiaohu Gao*. Cytosolic delivery of proteins by cholesterol tagging. Sci. Adv. 2020, 6, abb0310
5. Wanyi Tai, Xiaohu Gao*. Silencing ribonucleoprotein: a biomimetic platform for targeted siRNA delivery. Advanced Functional Materials 2019, 29, 1902221
6. Wanyi Tai, Xiaohu Gao*. Synthetic polymer tag for intracellular delivery of siRNA. Advanced Biosystems 2018, 2. 1800075
7. Wanyi Tai, Junwei Li, Eva Corey, Xiaohu Gao*. A ribonucleoprotein octamer for targeted siRNA delivery. Nature Biomedical Engineering 2018, 2(5), 326-337
8. Wanyi Tai, Xiaohu Gao*. Noncovalent tagging of siRNA with steroids for transmembrane delivery. Biomaterials 2018, 178. 720-727.
9. Wanyi Tai, Xiaohu Gao*. Functional peptides for siRNA delivery Advanced Drug Delivery Reviews 2017, 110–111, 157–168.
10. Wanyi Tai, Ran Mo, Jin Di, Vinayak Subramanian, Xiao Gu, Zhen Gu*. Bio-inspired nanovesicles for glucose-responsive release of insulin. Biomacromolecules 2014, 15(10), 3495-3502.
11. Wanyi Tai#, Ran Mo#, Yue Lu, Tianyue Jiang, Zhen Gu*. Folding graft copolymer with pendant drug segment for co-delivery of anticancer drugs. Biomaterials 2014, 35(25), 7194-7203.
12. Wanyi Tai, Zhijin Chen, Ashutosh Barve, Zhonghua Peng, Kun Cheng*. A novel rapamycin-polymer conjugate based on a new poly(ethylene glycol) multiblock copolymer. Pharmaceutical Research 2014, 31(3), 706-719
13. Wanyi Tai, Zhijin Chen, Kun Cheng*. Expression profile and functional activity of peptide transporters in prostate cancer cells. Molecular Pharmaceutics 2013, 10(2), 477-487
14. Wanyi Tai, Ravi S. Shukla, Bin Qin, Benyi Li, Kun Cheng*. Development of a peptide-drug conjugate for prostate cancer therapy. Molecular Pharmaceutics 2011, 8(3), 901-912
15. Wan-Yi Tai#, Run-Tao Zhang#, Yi-Ming Ma, Min Gu, Gang Liu, Jia Li, Fa-Jun Nan*. Design, synthesis, and biological evaluation of ring‐opened bengamide analogues. ChemMedChem 2011, 6(9), 1555-1558.
16. Wanyi Tai, Rubi Mahato, Kun Cheng*. The role of HER2 in cancer therapy and targeted drug delivery. Journal of Controlled Release 2010, 146(3), 264-275
17. Wanyi Tai, Bin Qin, Kun Cheng*. Inhibition of breast cancer cell growth and invasiveness by dual silencing of HER-2 and VEGF. Molecular Pharmaceutics 2010, 7(2), 543-556
18. Gang Liu#, Yi-Ming Ma#, Wan-Yi Tai#, Chuan-Ming Xie, Yu-Lin Li, Jia Li and Fa-Jun Nan*. 2008, Design, synthesis, and biological evaluation of caprolactam-modified bengamide analogues. ChemMedChem 2008, 3(1), 74–78.
19.Wanyi Tai, Zhen Gu*. Chapter 16 “Methods of folding a graft copolymer with dual anticancer drug and related applications” In Peter Grunwald edits “Biocatalysis & Nanotechnology” (2017), Pan Stanford Publishing Pte. Ltd.
20.Wanyi Tai, Kun Cheng*. Chapter 17 “Advanced drug delivery in cancer therapy” In Mitra AK, Lee C. Cheng K. edits “Advanced drug delivery” (2013), Wiley-Blackwell, John Wiley & Sons, Inc.
