Position: Special Researcher
School/Academic Group: School of Pharmaceutical Sciences
Email: luliwhu@whu.edu.cn
Education：
2003.09 - 2007.07 College of Life Science and Technology, Huazhong Agricultural University，Bachelor
2006.09 - 2012.12 College of Life Science and Technology, Huazhong Agricultural University，Ph.D.
Working Experience：
2014.04 - 2017.12 University of Wisconsin–Madison，Postdoc in Genetics
2017.12 - 2018.12 University of Wisconsin–Madison，Assistant Researcher
2019.09 - now Wuhan University, Special Researcher
Current Teaching Interests/Responsibilities:
Pharmaceutical Botany；Bioinformatics
Research Interests:
Elucidation of Molecular Biosynthetic Pathways for Plant-Derived Natural Products; Plant synthetic biology; Plant-based bio-pesticides; Plant-derived flavor compounds
Publications：
1. Yan Yao#, Fangfang Chen#, Chaoyan Wu#, Xiaosa Chang, Weijia Cheng, Qiuxia Wang, Zixin Deng, Tiangang Liu, Li Lu*. Structure-based virtual screening aids the identification of glycosyltransferases in the biosynthesis of salidroside. Plant Biotechnology Journal, 2025, https://doi.org/10.1111/pbi.70002
2. Peng Yao#, Qin He#, Ying Wang#, Danyang Sun, Xiangsong Chen*, Li Lu*. Genome-wide profiling and functional study of short N-terminal H2B variants in Arabidopsis. Journal of Advanced Research. 2025, https://doi.org/10.1016/j.jare.2024.12.001
3. Yao Zhi#, Chong Dai#, Xueting Fang, Xiaochun Xiao, Hui Lu, Fangfang Chen, Rong Chen, Weihua Ma, Zixin Deng, Li Lu*, Tiangang Liu*. Gene-Directed In Vitro Mining Uncovers the Insect-Repellent Constituent from Mugwort (Artemisia argyi). Journal of the American Chemical Society, 2024, 146 (45), 30883-30892.
4. Xiaosa Chang, Xueting Fang, Yan Yao, Zhenni Xu, Chaoyan Wu,* and Li Lu*. Identification and Characterization of Glycosyltransferases Involved in the Biosynthesis of Neodiosmin. Journal of Agricultural and Food Chemistry, 2024, 72 (8): 4348–4357.
5. Yu-Yu Zheng#, Lin-Hua Chen#, Bing-Liang Fan#, Zhenni Xu#, Qiuxia Wang, Bo-Yuan Zhao, Min Gao, Min-Hui Yuan, Muhammad Tahirul Qamar, Yuanyuan Jiang, Liu Yang, Lingqiang Wang, Weihui Li, Wenguo Cai, Chongjian Ma*, Li Lu*, Jia-Ming Song*, Ling-Ling Chen*. Integrative multi-omics profiling of passion fruit reveals the genetic basis for fruit color and aroma. Plant Physiology, 2024, 194(4):2491-2510.
6. Xiaomin Deng#, Ziling Ye#, Jingyu Duan, Fangfang Chen, Yao Zhi, Man Huang, Minjian Huang, Weijia Cheng, Yujie Dou, Zhaolin Kuang, Yanglei Huang, Guangkai Bian, Zixin Deng, Tiangang Liu* and Li Lu*. Complete pathway elucidation and heterologous reconstitution of (+)-nootkatone biosynthesis from Alpinia oxyphylla. New Phytologist. 2024, 241(2):779-792.
7. Weijia Cheng#, Xueting Fang#, Zhifeng Guan#, Yan Yao, Zhenni Xu, Yunya Bi, Kexin Ren, Jiwen Li, Fangfang Chen, Xiangsong Chen, Weihua Ma, Zhaohui Chu, Zixin Deng, Zhengyu Zhang*, Li Lu*. Functional characterization and structural basis of a reversible glycosyltransferase involves in plant chemical defense. Plant Biotechnology Journal. 2023, 21:2611-2624.
8. Weijia Cheng, Yan Yao, Qiuxia Wang, Xiaosa Chang, Zhuolin Shi, Xueting Fang, Fangfang Chen, Shixin Chen, Yonghong Zhang, Fan Zhang, Dongqing Zhu, Zixin Deng, Li Lu*. Characterization of benzylisoquinoline alkaloid methyltransferases in Liriodendron chinense provides insights into the phylogenetic basis of angiosperm alkaloid diversity. The Plant Journal. 2022, 112(2):535-548.
9. Kimpara S#, Lu L#, Hoang NM#, Zhu F, Bates PD, Daenthanasanmak A, Zhang S, Yang DT, Kelm A, Liu Y, Li Y, Rosiejka A, Kondapelli A, Bebel S, Chen M, Waldmann TA, Capitini CM, Rui L. EGR1 Addiction in Diffuse Large B-cell Lymphoma. Mol Cancer Res. 2021, 19(8):1258-1269.
10. Li Lu, Fen Zhu, Yangguang Li, Shuichi Kimpara, Nguyet Minh Hoang, Sheida Pourdashti and Lixin Rui*. Inhibition of the STAT3 target SGK1 sensitizes diffuse large B cell lymphoma cells to AKT inhibitors. Blood Cancer journal, 2019, 9 (43).
11. Li Lu#, Xiangsong Chen#, Shuiming Qian, Xuehua Zhong*. The plant-specific histone residue Phe41 is important for genome-wide H3.1 distribution. Nature communications, 2018, 9 (1), 630.
12. Li Lu#, Fen Zhu#, Meili Zhang#, Yangguang Li, Amanda C. Drennan, Shuichi Kimpara, Ian Rumball, Christopher Selzer, Hunter Cameron, Ashley Kellicut, Amanda Kelm, Fangyu Wang, Thomas A Waldmann*, Lixin Rui*. Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma. PNAS, 2018, 115 (3), E498-E505.
13. Zeng H#, Lu L#, Chan NT, Horswill M, Ahlquist P, Zhong X*, Xu W*. Systematic identification of Ctr9 regulome in ERα-positive breast cancer. BMC genomics, 2016, 17(1), 902.
14. Li Lu, Xiangsong Chen, Dean Sanders, Shuiming Qian, Xuehua Zhong*. High-resolution mapping of H4K16 and H3K23 acetylation reveals conserved and unique distribution patterns in Arabidopsis and rice. Epigenetics, 2015, 10 (11), 1044-1053.
15. Yang Lei#, Li Lu#, Hai-Yang Liu, Sen Li, Feng Xing, Ling-Ling Chen*. CRISPR-P: A web tool for synthetic single-guide RNA design of CRISPR-system in plants. Molecular Plant, 2014, 9:1494-1496.
16. Li Lu, Di Shao, Xianjing Qiu, Liang Sun, Xiangchun Zhou, Wenhao Yan, Lin Yang, Yuqing He, Sibin Yu, Yongzhong Xing*. Natural variation and artificial selection in four genes determine grain shape in rice. New Phytologist, 2013, 200:1269-1280.
17. Li Lu#, Wenhao Yan#, Weiya Xue, Di Shao, Yongzhong Xing*. Evolution and association analysis of Ghd7 in rice. PLoS ONE, 2012, 7: e34021.
18. Hui Li#, Li Lu#, Yanfang Heng, Rui Qin, Yongzhong Xing, Weiwei Jin*. Expression of CENH3 alleles in synthesized allopolyploid Oryza species. Journal of Genetics and Genomics, 2010, 37:703-711.
