Position: Professor, Doctoral advisor
School/Academic Group: School of Pharmaceutical Sciences
Email: lx@whu.edu.cn
Education：
1994 - 1998 Wuhan University，Bachelor
2000 - 2005 Wuhan University，Ph.D.
Working Experience：
2005 - 2008 Beth Israel Deaconess Medical Center, Harvard Medical School， Postdoc
2009 - 2016 Wuhan University, Associate Professor
2016 - now Wuhan University, Professor
Current Teaching Interests/Responsibilities:
Cell biology
Research Interests:
Regulatory mechanisms of tumor angiogenesis; Anticancer drugs; Antiviral therapeutics
Publications：
1. Hou S#, Niu G#, Liu X#, Bourbon PM, Zhang D, Cui P, Zhao K, Zhao D, Zeng H. A novel transcriptional complex on the VE-cadherin promoter regulated the downregulation of VE-cadherin in the Down Syndrome Candidate Region 1 isoform 1L-mediated angiogenesis. Microvasc Res. 2021 Nov;138:104209.
2. Xu J, Jiang Y, Wan L, Wang Q, Huang Z, Liu Y, Wu Y, Chen Z, Liu X*.Feeding Recombinant E. coli with GST[1]mBmKTX Fusion Protein Increases the Fecundity and Lifespan of Caenorhabditis elegans. Peptides. 2017 Jan. pii:S0196-9781(17)30008-6.
3. Chen L, Zhang J, Xu J, Wan L, Teng K, Xiang J, Zhang R, Huang Z, Liu Y, Li W, Liu X*. rBmαTX14 Increases the Life Span and Promotes the Locomotion of Caenorhabditis Elegans. PLoS One. 2016 Sep 9;11(9):e0161847.
4. Teng K,Deng C, Xu J, Men Q, Lei T, Di D, Liu T, Li W, Liu X*. Nuclear localization of TEF3-1 promotes cell cycle progression and angiogenesis in cancer. Oncotarget. 2016 Mar 22;7(12):13827-41.
5. Chen J, Zhang J, Xiang Y, Xiang L, Liu Y, He X, Zhou X, Liu X*, Huang Z*. Extracts of Tsai Tai (Brassica chinensis): enhanced antioxidant activity and anti-aging effects both in vitro and in Caenorhabditis elegans. Food &Function. 2016 Feb 17;7(2):943-52.
6. Yang F, Ai W, Jiang F, Liu X, Huang Z, Ai S, Preclinical Evaluation of an Epidermal Growth Factor Receptor-Targeted Doxorubicin-Peptide Conjugate: Toxicity, Biodistribution, and Efficacy in Mice. Journal of Pharmaceutical Sciences. 2016;105(2):639-649.
7. Qiao C, Jiang Y, Deng C, Huang Z, Teng K, Chen L, Liu X*. Characterization of the transcriptional activation domains of human TEF3-1 (transcription enhancer factor 3 isoform 1). Arch Biochem Biophys. 2015 Mar 1;569:54-61.
8. Liu T, Men Q, Wu G, Yu C, Huang Z, Liu X*, Li W*. Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells. Oncotarget.2015 Apr 10;6(10):7992-8006.
9. Wang H, Liu T, Li L, Wang Q, Yu C, Liu X*, Li W*. Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species. Cell Biosci. 2015 Jan 14;5:4.
10. Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, Li W, Liu X*. Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo. Int J Oncol.2015,46(1):360-8.
11. Liu X, Zhao D, James L, Li J, Zeng H. Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor. FASEB J.2011, 25:1188-97.
12. Liu X#, Zhao D#, Qin L, Li J, Zeng H.Transcription Enhancer Factor 3 (TEF3) Mediates the Expression of Down Syndrome Candidate Region 1 Isoform 1 (DSCR1-1L) in Endothelial Cells. J Biol Chem. 2008, 283:34159-67.
13. Qin L, Zhao D, Liu X, Nagy JA, Hoang MV, Brown LF, Dvorak HF, Zeng H.Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway. Mol Cancer Res. 2006 Nov;4(11):811-20.
14. Liu X#, Zhou W#, Qi Y. Expression of SLAM (CDw150) on SF9 cell surface mediates Measles Viral infection in the nonpermissive cells through SLAM/MVH interaction. Microbes Infect. 2005,7:1235-45.
15. Huang Y#, Liu X#, Dong L, Liu Z, He X, Liu W. Development of viral vectors for gene therapy for chronic pain. Pain Res Treat. 2011, 968218. doi: 10.1155/2011/968218
16. Yi C, Liu X, Liu Y, Lu S, Qi Y. Hemagglutinin protein of measles virus induces apoptosis of HeLa cells via bot extrinsic and intrinsic pathways. Can J Microbiol. 2013 , 59:814-24.
17. Li J, Chen Y, Wan J, Liu X, Yu C, Li W. ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells. Br J Pharmacol. 2014 Jul;171(13):3182-95.
18. Ai S, Jia T, Ai W, Duan J, Liu Y, Chen J, Liu X, Yang F, Tian Y, Huang Z. Targeted delivery of doxorubicin through conjugation with EGF receptor-binding peptide overcomes drug resistance in human colon cancer cells. Br J Pharmacol. 2013 Apr;168(7):1719-35
19. Ai S, Duan J, Liu X, Bock S, Tian Y, Huang Z. Biological evaluation of a novel Doxorubicin-peptide conjugate for targeted delivery to EGF receptor-overexpressing tumor cells. Mol Pharm. 2011, 8:375-86.
20. Li J, Chen Y, Wan J, Liu X, Yu C, Li W. ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21((CIP1/WAF1)) in human cancer cells. Br J Pharmacol. 2014 Jul;171(13):3182-95.
21. Mei L, Chen Y, Wang Z, Wang J, Wan J, Yu C, Liu X, Li W. Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21. Br J Pharmacol. 2015 May;172(9):2232-45.
