Position: Professor, Doctoral advisor
School/Academic Group: School of Pharmaceutical Sciences
Email: xhy78@whu.edu.cn
Education：
1993.09 – 1997.07 Tianjin University，Bachelor
1997.09 – 1999.11 Tianjin University，Master
2001.01 – 2005.07 University of Missouri，Ph.D.
Professional Memberships and/or Notable Appointments:
Chinese Journal of Medicinal Chemistry, Member of the Editorial Board
Wuhan University Journal of Natural Sciences, Member of the Editorial Board
Chinese Chemical Letters, Member of the Youth Editorial Board
Herald of Medicine, Member of the Editorial Board
Precision Medicine Branch, National Health Industry Enterprise Management Association, Member of Council
Chinese Society for Biochemistry and Molecular Biology, Member of the Proteomics Professional Committee
Molecular Imaging Professional Committee, Biophysical Society of China, Member of the Committee
China Medicinal Biotechnology Association, Member of the Pharmaceutical Analysis Technology Branch
Analytical Pharmacology Division, Chinese Pharmacological Society, Member of the Committee
Hubei Provincial Common Technology Drug & Pharmaceutical Material R&D Promotion Center for SMEs, Director
Hubei Association for Science and Technology Advancement, Member of the Standing Council
Working Experience：
1999.12 – 2000.07 Faculty of Pharmaceutical Sciences, Hokkaido University，Intern
2005.09 – 2007.09 Department of Chemistry, College of Arts and Sciences, Emory University，Postdoc
2007.10 – 2010.10 AMRI, Senior Researcher
2010.10 – now Wuhan University, Professor
2017.12 – now Tibet University, Professor
Research Interests:
Visualized tumor and virus infection mechanism research and drug development
Publications：
1.Bingbing Ding†, Yuling Xiao†,Hui Zhou†, Xiao Zhang, Chunrong Qu, Fuchun Xu, Zixin Deng, Zhen Cheng, Xuechuan Hong*, Polymethine thiopyrylium fluorophores with absorption beyond 1000 nm for biological imaging in the second near-infrared sub-window. J. Med. Chem. 2019, 62, 2049−2059.
2.Chunrong Qu†, Mingmin Ding†, Yingmin Zhu†, Yungang Lu, Juan Du, Melissa R. Miller, Jinbin Tian, Jinmei Zhu, Jian Xu, Meng Wen, AGA Er-Bu, Jule Wang, Yuling Xiao, Meng Wu, Owen B. McManus, Min Li, Jilin Wu, Huai-rong Luo, Zheng-yu Cao, Bing Shen, Hongbo Wang*, Michael X. Zhu*, Xuechuan Hong*，Pyrazolopyrimidines as potent stimulators for transient receptor potential canonical 3/6/7 channels. J. Med. Chem. 2017, 60(11), 4680−4692.
3.Alexander L. Antaris†, Hao Chen†, Kai Cheng, Yao Sun, Guosong Hong, Chunrong Qu, Shuo Diao, Zixin Deng, Xianming Hu, Bo Zhang, Xiaodong Zhang, Omar K. Yaghi, Zita R. Alamparambil, Xuechuan Hong*, Zhen Cheng* and Hongjie Dai*. A small molecule dye for NIR II imaging. Nat. Mater. 2016, 15(2), 235–242.
4.Yao Sun, Xiaowei Ma, Kai Cheng, Biying Wu, Jianli Duan, Hao Chen, Lihong Bu, Ruiping Zhang, Xianming Hu, Zixin Deng, Lei Xing, Xuechuan Hong*, Zhen Cheng*. Strained Cyclooctyne as a Molecular Platform for Construction of Multimodal Imaging Probes. Angew. Chem. Int. Ed. 2015, 54(20), 5981-5984.
5.Alexander L. Antaris,†, Hao Chen†, Shuo Diao, Zhuoran Ma, Zhe Zhang, Shoujun Zhu, Joy Wang, Alexander Lozano, Quli Fan, Leila Chew, Mark Zhu, Kai Cheng, Xuechuan Hong*, Hongjie Dai*, Zhen Cheng*, A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging. Nat. Commun. 2017，8,15269.
6.Yao. Sun†, Xiaodong Zeng†, Yuling Xiao†, Changhao Liu, Hua Zhu, Hui Zhou, Ziyang Chen, Fuchun Xu, Jule Wang, Mengyue Zhu, Junzhu Wu, Zixing Deng, Zhen Cheng*, Xuechuan Hong*, Dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery. Chem. Sci. 2018, 9, 2092–2097.
7.Jiacheng Lin†, Xiaodong Zeng†, Yuling Xiao†, Lin Tang, Jinxia Nong, Yufang Liu, Hui Zhou, Bingbing Ding, Fuchun Xu, Hanxing Tong, Zixin Deng, Xuechuan Hong*, Novel near-Infrared II aggregation-induced emission dots for in vivo bioimaging. Chem. Sci. 2019, 10, 1219-1126.
8.Yao Sun†, Mingmin Ding†,Xiaodong Zeng†, Yuling Xiao†, Huaping Wu, Hui Zhou, Bingbing Ding, Chunrong Qu, Wei Hou, AGA Er-Bu, Yejun Zhang, Zhen Cheng , Xuechuan Hong*, Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery. Chem. Sci. 2017, 8, 3489-3493.
9.Yao Sun†,Chunrong Qu†, Hao Chen, Maomao He, Chu Tang, Kangquan Shou, Su Hong, Meng Yang, Yuxing Jiang, Bingbing Ding, YulingXiao, Lei Xing, Xuechuan Hong*，Zhen Cheng*，Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer, Chem. Sci. 2016, 7，6203-6207.
10.Yao Sun, Suhyun Hong, Xiaowei Ma, Kai Cheng, Jing Wang, Zhe Zhang, Meng Yang, Yuxin Jiang, Xuechuan Hong*, Zhen Cheng*, Recyclable Cu(I)/Melanin dots for cycloadditions, bioconjugation and cell labeling. Chem. Sci. 2016, 7，5888-5892.
11.Hao Chen, Maomao He, Yaya Wang, Linhui Zhai, Yongbo Cui, Yangyan Li, Yan Li, Haibing Zhou*, Xuechuan Hong*, Zixin Deng, Metal-free direct amidation of peptidyl thiol esters with amino acid esters. Green Chem. 2011, 13, 2723.
12.Chunrong Qu, † Yuling Xiao, † Hui Zhou, Bingbing Ding, Anguo Li, Jiacheng Lin, Xiaodong Zeng, Hao Chen, Kun Qian, Xiao Zhang, Wei Fang, Junzhu Wu, Zixin Deng, Zhen Cheng,* Xuechuan Hong*. Quaternary ammonium salt based NIR-II probes for In vivo imaging. Adv. Optical Mater. 2019, 1900229.
13.Hui Zhou, Han Yang, Lin Tang, Yue Wang, Yang Li, Nan Liu, Xiaodong Zeng, Yu Yan, Junzhu Wu, Shizhen Chen, Long Xiao, Yi Yu, Zixin Deng, Hai Deng, Xuechuan Hong, * Yuling Xiao* Mn-loaded apolactoferrin dots for in vivo MRI and NIR-II cancer imaging. J. Mater. Chem. C 2019, 7, 9448-9454
14.Yingmin Zhu, Yungang Lu, Chunrong Qu, Melissa Miller, Jinbin Tian, Dhananjay P Thakur, Jinmei Zhu, Zixin Deng, Xianming Hu, Meng Wu, Owen B McManus, Min Li, Xuechuan Hong*, Michael X Zhu*, Huai-Rong Luo*, Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. 2015, Bri. J. Pharm. 172(14), 3495-3509.
15.Mingmin Ding†, Hongbo Wang†, Chunrong Qu†, Fuchun Xu†, Yingmin Zhu, Guangyao Lv, Yungang Lu, Qingjun Zhou, Hui Zhou, Xiaodong Zeng, Jingwen Zhang, Chunhong Yan, Jiacheng Lin, Huai-Rong Luo, Zixing Deng, Yuling Xiao, Jinbin Tian, Michael X. Zhu, Xuechuan Hong*, Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer. Cancer Lett. 2018, 432, 47–55.
16.Xiaodong Zeng†, Yuling Xiao†, Jiacheng Lin, Shanshan Li, Hui Zhou, Jinxia Nong, Guozhen Xu, Hongbo Wang, Fuchun Xu, Junzhu Wu, Zixin Deng, Xuechuan Hong*, Near-Infrared II dye-protein complex for biomedical imaging and imaging-guided photothermal therapy. Adv. Healthcare Mater. 2018, 7, 1800589.
17.Xiaodong Zeng,† Ziyang Chen,† Lin Tang,† Han Yang, Nan Liu, Hui Zhou, Yang Li, Junzhu Wu, Zixin Deng, Yi Yu, Hai Deng,* Xuechuan Hong* and Yuling Xiao*. A novel near-infrared fluorescent light-up probe for tumor imaging and drug-induced liver injury detection. Chem. Commun. 2019, 55, 2541-2544.
18.Jing Yang, Xuechuan Hong*, New glowing dyes in vivo imaging with wavelengths beyond 1500 nm. Sci. China Chem. 2019, 62(1), 7-8.
19.Jinping Li, Jun Lou, Zhiming Wang, Ting Wang, Yuling Xiao, Xianming Hu, Peng Liu, Xuechuan Hong*, Design, synthesis and pharmacological evaluation of novel N-(2-(1,1-dimethyl-5, 7-dioxo-4, 6-diazaspiro[2.4]heptan-6-yl)ethyl) sulfonamide derivatives as potential anticonvulsant agents. Eur. J. Med. Chem. 2015, 92, 370-376.
20.Jun Lou, Xiaoyan Yang, Zhigang Rao,Wenwen Qi, Jinhui Li, HaiyuWang, Yuxi Li, Jinping Li, Zhiming Wang, Xianming Hu, Peng Liu*, Xuechuan Hong*, Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors. Eur. J. Med. Chem. 2014, 83, 466-473.
