Position: Professor
School/Academic Group: School of Pharmaceutical Sciences
Email: kuihong31@whu.edu.cn
Education：
1984.09 - 1988.07 Wuhan University, Department of Biology, Bachelor
1988.09 - 1991.07 Hainan University, Master
1995.09 - 1998.07 Nanjing Agricultural University, Ph.D.
Professional Memberships and/or Notable Appointments:
Chinese society of Oceanography, Vice chairman of marine microbial resources professional committee
Chinese Pharmacological Society, Member of the marine pharmacology Committee
Chinese Pharmaceutical Association, Member of marine pharmaceutical professional committee
Working Experience：
1991.07 - 1999.09 Teaching Assistant, Lecturer, Associate Professor
1999.09―2000.04 Chinese Academy of Tropical Agricultural Sciences, Associate Professor
2000.04 - 2002.04 South China Tropical Agricultural University, Associate Professor
2006.09 - 2010.12 Chinese Academy of Tropical Agricultural Sciences, Professor
2010.12 - now Wuhan University, Professor
Current Teaching Interests/Responsibilities:
Microbiology
Research Interests:
Evaluation and preclinical study of the drug properties of antitumor drugs
Publications：
1. Liang JJ, Yu WL, Yang L, Qin KM, Yin YP, Li D, Ni YH, Yan JJ, Zhong YX, Deng ZX, Hong K*. Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent. Eur J Med Chem. 2022 Mar 23; 236:114313. doi: 10.1016/j.ejmech.2022.114313.
2. Wen H, Zhong Y, Yin Y, Qin K, Yang L, Li D, Yu W, Yang C, Deng Z, Hong K*. A marine-derived small molecule induces immunogenic cell death against triple-negative breast cancer through ER stress-CHOP pathway. Int J Biol Sci 2022; 18(7):2898-2913. doi:10.7150/ijbs.70975
3. Yan, J.; Pang, J.; Liang, J.; Yu, W.; Liao, X.; Aobulikasimu, A.; Yi, X.; Yin, Y.; Deng, Z.; Hong K*. The Biosynthesis and Transport of Ophiobolins in Aspergillus ustus 094102. Int. J. Mol. Sci. 2022, 23, 1903. https://doi.org/10.3390/ ijms23031903 (IF5.9238)
4. Liang JJ, Yu WL, Yang L, Xie BH, Qin KM, Yin YP, Yan JJ, Gong S, Liu TY, Zhou HB, Hong K*. Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment. Eur J Med Chem. 2022 Feb 5; 229:114081. doi: 10.1016/j.ejmech.2021.114081.
5. Guo J, Cai YS, Cheng F, Yang C, Zhang W, Yu W, Yan J, Deng Z, Hong K. Genome Mining Reveals a Multiproduct Sesterterpenoid Biosynthetic Gene Cluster in Aspergillus ustus. Org Lett. 2021 Jan 22. doi: 10.1021/acs.orglett.0c03996. Epub ahead of print. PMID: 33480256.
6. Ding, W.; Uvarani, C.; Wang, F.; Xue, Y.; Wu, N.; He, L.; Tian, D.; Chen, M.; Zhang, Y.; Hong, K.; Tang, J. New Ophiobolins from the Deep-Sea Derived Fungus Aspergillus sp. WHU0154 and Their Anti-Inflammatory Effects. Mar. Drugs 2020, 18 (11), 575.
7. Gou, X; Jia, J; Xue, Y; Ding, W; Dong, Z; Tian, D; Chen, M; Bi, H*; Hong, K*; Tang, J*. New pyrones and their analogs from the marine mangrove derived Aspergillus sp. DM94 with antibacterial activity against Helicobacter pylori. Applied Microbiology and Biotechnology (2020), 104(18):7971-7978. doi.org/10.1007/s00253-020-10792-9.
8. Xu, D.; Tian, E.; Kong, F.; Hong, K*. Bioactive molecules from mangrove Streptomyces qinglanensis 172205. Mar. Drugs 2020, 18, 255. （IF4.073）
9. ZhangC, HongK*. Production of terpenoids by synthetic biology approaches. Front. Bioeng. Biotechnol., 2020;8:347 24 April 2020 | https://doi.org/10.3389/fbioe.2020.00347 (IF5.122)
10. Tian W, Yang L, Wu D, Deng Z and Hong K*. Toxicity, pharmacokinetics, and gut microbiome of oral administration of sesterterpene MHO7 derived from a marine fungus. Mar. Drugs 2019, 17, 667; doi:10.3390/md17120667 （IF4.073）
11. Yuan W, Lv S, Chen L, Zhao Y, Deng Z, Hong K*. Production of sesterterpene ophiobolin by a bifunctional terpene synthase in Escherichia coli. Appl Microbiol Biotechnol. 2019;103(21-22):8785-8797. 2019 Sep 12. doi: 10.1007/s00253-019-10103-x. [Epub ahead of print] PubMed PMID: 31515597.
12. Zhao Y, Zhao C, Lu J, Wu J, Li C, Hu Z, Tian W, Yang L, Xiang J, Zhou H, Deng Z, Huang J*, Hong K*, Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader, Pharmacological Research (2019), https://doi.org/10.1016/j.phrs.2019.104294
13. Kamjam M, Nopnakorn P, Zhang L, Peng F, Deng Z, Hong K*. Streptomyces Polaris sp. nov. and Streptomyces septentrionalis sp. nov., isolated from frozen soil. Antonie Van Leeuwenhoek. 2019, 112(3), 375-387Sep 24. doi: 10.1007/s10482-018-1166-x. [Epub ahead of print] PubMed PMID: 30251113.
14. Yan J, Guo J, Yuan W, Mai W, Hong K*. Identification of enzymes involved in sesterterpene biosynthesis in marine fungi. Methods Enzymol. 2018;604:441-498.doi: 10.1016/bs.mie.2018.04.023. Epub 2018 May 2. PubMed PMID: 29779663.
