Position: Professor
School/Academic Group: School of Pharmaceutical Sciences
Email: shichen@whu.edu.cn
Education：
1994 – 2000 Huazhong Agricultural University, Bachelor and Master
2000 – 2004 Shanghai Jiao Tong University, Ph.D.
2001 – 2002 Korea Advanced Institute of Science and Technology (KAIST), Visiting Ph.D.
Professional Memberships and/or Notable Appointments:
Fellow of American Academy of Microbiology
Member of the International Committee of the International Association for chemical biology
Working Experience：
2005 – 2007 Massachusetts Institute of Technology (MIT), Postdoc
2007 – 2011 Harvard University, Research Scientist
2011 – Present Wuhan University, Professor
Research Interests:
Genome Editing, Modification, and Synthetic Biology; Design and Engineering of Innovative Drugs
Publications：
1. Susu Jiang#, Chao Chen#, Wanqiu Huang, Yue He, Xuan Du, Yi Wang, Hongda Ou, Zixin Deng, Congrui Xu, Lixu Jiang, Lianrong Wang, Shi Chen*. A widespread phage-encoded kinase enables evasion of multiple host antiphage defense systems. Nature Microbiology, 2024, DOI: 10.1038/s41564-024-01851-2.
2. Tianchen An#, Qian Tan#, Lixu Jiang, Li Liua, Xing Jiang, Liying Liu, Xiaofei Chang, Xihao Tian, Zixin Deng, Shuai Gao, Lianrong Wang*, Shi Chen *. An unusual DNA backbone sulfur modification pathway via an adenylated intermediate modulates the Tdp antiphage defense machinery in thermophiles. Nature Chemical Biology, 2024. Accepted.
3. Dan Wu, Yaqian Tang, Siwei Chen, Yue He, Xiaofei Chang, Wenzhong Zheng, Zixin Deng, Zhiqiang Li, Lianrong Wang*, Geng Wu*, Shi Chen*. The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex. Nature Catalysis. 2022, December, 5, 1131–1144.
4. Chao Chen#, Lianrong Wang#, Si Chen, Xiaolin Wu, Meijia Gu, Xi Chen, Susu Jiang, Yunfu Wang Zixin Deng, Peter C. Dedon, Shi Chen*. Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes. Proc Natl Acad Sci U S A, 2017, 114(17): 4501–4506. doi: 10.1073/pnas.1702450114.
5. Lei Xiong#, Siyi Liu#, Si Chen#, Yao Xiao#, Bochen Zhu, Yali Gao, Yujing Zhang, Beibei Chen, Jie Luo, Zixin Deng, Xiangdong Chen, Lianrong Wang, Shi Chen*. A new type of DNA phosphorothioation-based antiviral 1 system in archaea. Nature Communications, 2019, 10:1688 | https://doi.org/10.1038/s41467-019-09390-9.
6. Tong Tong#, Si Chen#, Lianrong Wang#, You Tang#, Jae Yong Ryu, Susu Jiang, Xiaolin Wu, Chao Chen, Jie Luo, Zixin Deng, Zhiqiang Li, Sang Yup Lee*, Shi Chen*. Occurrence, evolution, and functions of DNA phosphorothioate epigenetics in bacteria, Proc Natl Acad Sci U S A, 2018,115(13):2988-2996. doi:10.1073/pnas.1721916115.
7. Haiyan Gao#, Xinqi Gong#, Jinchuan Zhou, Yubing Zhang, Jinsong Duan, Yue Wei, Liuqing Chen, Zixin Deng, Jiawei Wang, Shi Chen*, Geng Wu*, Lianrong Wang*. Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE. Nature Communications, 2022, November, 13:6773.
8. Yajie Wang, Yuting Yang, Ying Cai, Ayikaimaier Aobulikasimu, Yuexin Wang, Chuanwei Hu, Zhikang Miao, Yue Shao, Mengna Zhao, Yue Hu, Chang Xu, Xinjun Chen，Zhiqiang Li, Jincao Chen, Lianrong Wang*, Shi Chen*. Endo‐Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1‐Null Rat Hippocampus. Advanced Science, 2024, doi.org/10.1002/advs.202407709.
9. Luojia Chen#, Ming-Yu Wu#,*, Si-Ling Chen#, Rui Hu, Yifei Wang, Weijuan Zeng, Shun Feng, Min Ke*, Lianrong Wang*, Shi Chen*, Meijia Gu*. The Guardian of Vision: Intelligent Bacteriophage-Based Eyedrops for Clinical Multidrug-Resistant Ocular Surface Infections. Advanced Materials, 2024, doi.org/10.1002/adma.202407268.
10. Lianrong Wang*, Yaqian Tang, Zixin Deng, Shi Chen*. DNA Phosphorothioate Modification Systems and Associated Phage Defense Systems. Annual Review of Microbiology, 2024, DOI.org/10.1146/annurev-micro-041222-014330.
11. Pengqing Nie, Cheng Zhang, Fengyi Wu, Shi Chen*, Lianrong Wang*. The Compromised Fanconi Anemia Pathway in Prelamin A-Expressing Cells Contributes to Replication Stress-Induced Genomic Instability. Advanced Science, 2024, DOI: 10.1002/advs.202307751.
12. Yachen Wu#, Wenzhong Zheng, Guofeng Xu, Lijun Zhu, Zhiqiang Li, Jincao Chen, Lianrong Wang*, Shi Chen*. C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport. Cell Death & Differentiation, 2024, DOI.org/10.1038/s41418-024-01312-7.
13. Ming-Yu Wu#, Luojia Chen#, Qingrong Chen, Rui Hu, Xiaoyu Xu, Yifei Wang, Jie Li, Shun Feng, Changjiang Dong, Xiao-Lian Zhang, Zhiqiang Li, Lianrong Wang*, Shi Chen*, Meijia Gu*. Engineered Phage with Aggregation-Induced Emission Photosensitizer in Cocktail Therapy against Sepsis. Advanced Materials. 2023, 35, 2208578, DOI: 10.1002/adma.202208578.
14. Xuan Zou, Xiaohong Xiao, Ziran Mo, Yashi Ge, Xing Jiang, Ruolin Huang, Mengxue Li, Zixin Deng, Shi Chen*, Lianrong Wang*, Sang Yup Lee*. Systematic strategies for developing phage resistant Escherichia coli strains. Nature Communications, 2022, 13: 4491.
15. Ming-Yu Wu#, Xiaoyu Xu#, Rui Hu#, Qingrong Chen, Luojia Chen, Yuncong Yuan, Jie Li, Li Zhou, Shun Feng, Lianrong Wang*, Shi Chen*, Meijia Gu*. A membrane-targeted photosensitizer prevents drug resistance and induces immune response in treating Candidiasis. Advanced Science. 2023; e2207736. DOI: 10.1002/advs.202207736.
16. Bo Cao#, Chao Chen#, Michael S. DeMott#, Qiuxiang Cheng, Tyson A. Clark, Xiaolin Xiong, Xiaoqing Zheng, Vincent Butty, Stuart S. Levine, George Yuan, Matthew Boitano, Khai Luong, Yi Song, Xiufen Zhou, Zixin Deng, Stephen W. Turner, Jonas Korlach, Delin You*, Lianrong Wang*, Shi Chen*, Peter C. Dedon. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature Communications, 2014, 5, doi:10.1038/ncomms4951.
17. Lianrong Wang, Susu Jiang, Chao Chen, Wei He, Xiaolin Wu, Fei Wang, Tong Tong, Xuan Zou, Zhiqiang Li, Jie Luo, Zixin Deng, Shi Chen*. Synthetic genomes: from DNA synthesis to genome design. Angew Chem Int Ed., 2018, 57: 2~11.
18. Meijia Gu#, Xiaoyu Xu#, Ming-Yu Wu#, Chao Chen, Yuncong Yuan, Qingrong Chen, Yidan Sun, Luojia Chen, Chao Shen, Peng Guo, Shujie Liu, Engui Zhao*, Shi Chen*, Sijie Chen*. Simultaneous photodynamic eradication of tooth biofilm and tooth whitening with an aggregation-induced emission luminogen. Advanced Science, 2022, 9, 2106071.
19. Yanlian Chen, Zhiqiang Deng, Shuai Jiang, Qian Hu, Haiying Liu, Zhou Songyang, Wenbin Ma, Shi Chen*, Yong Zhao*. Human cells lacking coilin and Cajal bodies areproficient in telomerase assembly, trafficking and telomere maintenance. Nucleic Acids Research, 2014, 1-11, doi: 10.1093/nar/gku1277.
20. Lianrong Wang, Shi Chen*, Kevin L. Vergin, Stephen J. Giovannoni, Simon W. Chan, Michael S. DeMott, Koli Taghizadehe, Otto X. Cordero, Michael Cutler, Sonia Timberlake, Eric J. Alm, Martin F. Polz, Jarone Pinhassi, Zixin Deng, Peter C. Dedon*. DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci U S A, 2011, 108 (7): 2963-2968.
21. Wenzhong Zheng#, Kexin Wang#, Yachen Wu#, Ge Yan, Chi Zhang, Zhiqiang Li, Lianrong Wang*, Shi Chen*. C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α. Theranostics, 2022, 12, Issue 17.
22. Zhiqiang Deng, Junghyun Lim, Qian Wang, Kerry Purtell, Shuai Wu, Gloria M. Palomo, Haiyan Tan, Giovanni Manfredi, Yanxiang Zhao, Junmin Peng, Bo Hu, Shi Chen*, Zhenyu Yue*. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/ NRF2 anti-oxidative stress pathway. Autophagy, 2019. DOI: 10.1080/15548627.2019.1644076.
23. Yajie Wang#, Zhikang Miao# , Chang Xu, Ying Cai, Yuting Yang, Yue Hu, Mengna Zhao, Yue Shao, Zhiqiang Li, Jincao Chen, Shi Chen*, Lianrong Wang*. Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats. Cell Death & Disease, 2023 May 13;14(5):325. DOI: 10.1038/s41419-023-05846-5.
24. Huang Q, Wang F, Yuan C, He Z, Rao L, Cai B, Chen B, Jiang S, Li Z, Chen J, Liu W, Guo F, Ao Z*, Shi Chen*, Zhao X*. Gelatin nanoparticle-coated silicon beads for density-selective capture and release of heterogeneous circulating tumor cells with high purity. Theranostics, 2018, 8(6): 1624~1635.
25. Deng Z, Purtell K Lachance V, Wold M, Shi Chen*, Yue Z*. Autophagy Receptors and Neurodegenerative Diseases. Trends in Cell Biology, 2017, 27(7).491~504. doi.org/10.1016/j.tcb.2017.01.001.
26. Fei Wang#, Lianrong Wang#, Xuan Zou, Suling Duan, Zhiqiang Li, Zixin Deng, Jie Luo, Sang Yup Lee*, Shi Chen*. Advances in CRISPR-Cas systems for RNA targeting, tracking and editing. Biotechnology Advances. 2019 Mar 27. pii: S0734-9750(19)30052-7. doi: 10.1016/j.biotechadv.2019.03.016.
27. Lianrong Wang, Susu Jiang, Zixin Deng, Peter Dedon, Shi Chen*. DNA phosphorothioate modification–a new multi-functional epigenetic system in bacteria. FEMS Microbiology Reviews. 2019, 43(2), 109–122. https://doi.org/10.1093/femsre/fuy036.
28. Meijia Gu#*, Luojia Chen#, Rui Hu, Qingrong Chen, Jianbo Liu*, Lianrong Wang*, Shi Chen*. Aggregation-induced emission: recent applications in infectious diseases. SCIENCE CHINA Chemistry, 2023 Oct 24. doi.org/10.1007/s11426-023-1825-7.
29. Zhiqiang Deng, Patricia Sheehan, Shi Chen*, Zhenyu Yue*. Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease? Molecular Neurodegeneration (2017) 12:90. DOI 10.1186/s13024-017-0232-6.
30. Xuan Zou#, Lianrong Wang#, Zhiqiang Li, Jie Luo, Yunfu Wang, Zixin Deng, Shiming Du, Shi Chen*. Genome engineering and modification toward synthetic biology for the production of antibiotics. Medicinal Research Reviews, 2018, 38(1): 229~260.
31. Shi Chen*, Lianrong Wang, Zixin Deng*. Twenty years hunting for sulfur in DNA. Protein & Cell, 2010, 1(1): 14-21.
