Position: Professor
School/Academic Group: School of Pharmaceutical Sciences
Email: pengch@whu.edu.cn
Education：
2004.09 - 2008.07 Northeast Normal University，Bachelor in Biological Science
2008.09 - 2013.11 University of science and technology of China，Ph.D.
Working Experience：
2014.05 - 2019.05 Department of Physiology & Biophysics, School of Medicine, University of California, Irvine，Postdoc
2019.05 - 2021.11 Department of Physiology & Biophysics, School of Medicine, University of California, Irvine，Assistant Project Scientist
2021.11 - now School of Pharmaceutical Sciences, Wuhan University, Professor
Current Teaching Interests/Responsibilities:
Biochemistry
Research Interests:
Molecular Mechanisms of Pathogen Effector-Host Interactions; Structure-Based Rational Design of Targeted Therapeutics and Vaccines
Publications：
1. Chen, P*., Tao, L*., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M#. & Jin, R#. (2018) Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Science. 360, 664-669.
2. Chen, P., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K. & Jin, R. (2019) Structure of the full-length Clostridium difficile toxin B, Nature Structural & Molecular Biology. 26, 712-719.
3. Chen, P*., Zeng, J*., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, Ralf., Huang, L., Dong, M#. & Jin, R#. (2021) Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Nature Communications. 12, 3748.
4. Chen, P., Tao, L., Liu, Z., Dong, M. & Jin, R. (2019) Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, The FEBS Journal. 286, 874-881.
5. Chen, P., & Jin, R. (2021). Receptor binding mechanisms of Clostridioides difficile toxin B and implications for therapeutics development, The FEBS Journal. doi:10.1111/febs.16310
6. Chen, P., Liu, Z., Wang, X., Peng, J., Sun, Q., Li, J., Wang, M., Niu, L., Zhang, Z., Cai, G#., Teng, M#. & Li, X#. (2015) Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations, PloS one. 10.
7. Chen, P., Li, J., Ma, J., Teng, M. & Li, X. (2013) A Small Disturbance, But a Serious Disease: The Possible Mechanism of D52H-Mutant of Human PRS1 That Causes Gout, IUBMB Life. 65, 518-525.
8. Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M#. & Li, X#. (2014) Crystal structure of DnaT(84-153)-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Nucleic Acids Research. 42, 9470-9483.
9. Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M. & Jin, R. (2021) Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, Science Advances 7, eabi4582.
