王隆飞 

职务/职称：教授、博士生导师 

教育经历：

09/2001 –07/2005 华中农业大学，生物技术学士学位

09/2005 – 07/2011 中国科学院生物物理研究所，生物化学与分子生物学博士学位

研究经历：

07/2011 – 09/2011 中国科学院生物物理研究所，助理研究员

10/2011 – 04/2017 哈佛医学院，博士后

05/2017 – 07/2021 哈佛医学院波士顿儿童医院，讲师

09/2021 – 至今  太阳成集团tyc234cc，教授

研究方向：

研究领域：分子免疫学，结构药理学

研究兴趣：

    1.阐释宿主细胞防御病原体的分子机制

    2.研究免疫细胞表面受体的信号传导的结构基础

    3.研发可用于调控免疫信号通路的小分子和生物大分子（抗体，肽段，核酸等） 

荣誉奖励：

2019年获哈佛杰出华人生命科学研究奖

2022年入选“武汉英才”

学术论文（*共同第一作者，#共同通讯作者）：

1. Li J*, Cheng R*, Wang Z*, Yuan W, Xiao J, Zhao X, Du X, Xia S, Wang L, Zhu B#, Wang L#. Structures and activation mechanism of the Gabija anti-phage system. Nature 2024, 629(8011):467-73

2. Yan Y*, Xiao J*, Huang F*#, Xian W*, Yu B, Cheng R, Wu H, Lu X, Wang X, Huang W, Li J, Oyejobi GK, Robinson CV, Wu H, Wu D#, Liu X#, Wang L#, Zhu B#. Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway. Nature Microbiology 2024, 9:1566-1578.

3. Li J*, Wang L*, Hahn Q, Nowak RP, Viennet T, Orellana E, Burman SSR, Yue H, Hunkeler M, Fontana P, Wu H, Arthanari H, Fischer E, Gregory RI. Structural basis of m7G tRNA modification and regulation by METTL1-WDR4. Nature 2023, 613(7943):391-397.

4. Wang L*, Fu TM*, Zhou Y, Xia S, Greka A, and Wu H. Structures and gating mechanism of human TRPM2. Science 2018, 362: 1377.

5. Wang L^#, Wu D, Robinson CV, Fu TM^#. Identification of mEAK-7 as a human V-ATPase regulator via cryo-EM data mining. Proceedings of the National Academy of Sciences 2022, 119(35), e2203742119.

6. Wang L^#, Wu D, Robinson VC, Wu H^#, Fu TM^#. Structures of a complete human V-ATPase reveal mechanisms of its assembly Molecular Cell 2020, 80 (3), 501-511.
   

7. Vora SM*, Fontana P*, Mao T, Leger V, Zhang Y, Fu TM, Lieberman J, Gehrke L, Shi M*^#, Wang L*^#, Iwasaki A^#, Wu H^#. Targeting Stem-loop 1 of the SARS-CoV-2 5’UTR to suppress viral translation and Nsp1 evasion. Proceedings of the National Academy of Sciences 2022, 119(9), e2117198119.

8. Yu C*, Wang L*, Rowe RG, Han A, Jia W, McMahon C, Baier AS, Huang YC, Marion W, Pearson DS, Kruse AC, Daley GQ, Wu H, Sliz P. A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7. Proceedings of the National Academy of Sciences 2020, 117 (9) 4653-4663.

9. Wang L*, Rowe RG*, Jaimes A, Yu C, Nam Y, Pearson DS, Zhang J, Xie X, Marion W, Heffron GJ, Daley GQ, Sliz P. Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28. Cell Reports 2018, 23: 3091-3101.

10. Wang L*, Nam Y*, Lee AK, Yu C, Roth K, Chen C, Ransey EM, Sliz P. LIN28 zinc knuckle domain is required and sufficient to induce let-7 oligouridylation. Cell Reports 2017, 18: 2664-2675.
    

11. Zheng W*, Shen C*, Wang L*, Rawson S*, Xie WJ, Nist-Lund C, Wu J, Shen Z, Xia S, Holt JR, Wu H, Fu TM. PH Regulates Potassium Conductance and Drives a Constitutive Proton Current in Human TMEM175. Science Advance 2022, 8(12), eabm1568.

12. Gu L*, Wang L*, Chen H*, Hong J*, Shen Z, Dhall A, Lao T, Liu C, Wang Z, Xu Y, Tang HW, Chakraborty D, Chen J, Liu Z, Rogulja D, Perrimon N, Wu H, Shi Y. CG14906 (mettl4) mediates m 6 A methylation of U2 snRNA in Drosophila. Cell Discovery 2020, 6 (1), 1-4.

13. Wang L, Wu H. Keeping the Death Protein in Check. Immunity 2019, 51: 1-2 (Preview).

14. Wang L*, Negro R*, Wu H. TRPM2, linking oxidative stress and Ca2+ permeation to NLRP3 inflammasome activation. Current Opinion in Immunology 2020, 62:131-135 (Review).

15. Wang L*, Sharif H*, Vora SM, Zheng Y, Wu H. Structures and functions of the inflammasome engine. The Journal of Allergy and Clinical Immunology 2021, 147(6) (Review).
    

16. Xia S*, Wang L*, Fu TM, Wu H. Mechanism of TRPM2 channel gating revealed by cryo-EM. FEBS Journal 2019, 286: 3333-3339 (Snapshots).
    

17. Huang F, Lu X, Yu C, Sliz P, Wang L^#, Zhu B^#. Molecular dissection of the primase and polymerase activities of deep‐sea phage NrS‐1 primase-polymerase. Frontiers in Microbiology 2021, 3887.
    

18. Wang L^#, Yang Q, Jaimes A, Wang T, Strobelt H, Chen J, Sliz P^#. MightyScreen: an open-source visualization application for screening data analysis. SLAS DISCOVERY 2018, 23: 218-223.